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Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers

Despite the significant progress in cancer treatment, new anticancer therapeutics drugs with new structures and/or mechanisms are still in urgent need to tackle many key challenges. Drug repurposing is a feasible strategy in discovering new drugs among the approved drugs by defining new indications....

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Autores principales: Xu, Peng, Zhang, Shaobo, Tan, Lili, Wang, Lei, Yang, Zhongwei, Li, Jinbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851418/
https://www.ncbi.nlm.nih.gov/pubmed/35186766
http://dx.doi.org/10.3389/fonc.2022.836882
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author Xu, Peng
Zhang, Shaobo
Tan, Lili
Wang, Lei
Yang, Zhongwei
Li, Jinbao
author_facet Xu, Peng
Zhang, Shaobo
Tan, Lili
Wang, Lei
Yang, Zhongwei
Li, Jinbao
author_sort Xu, Peng
collection PubMed
description Despite the significant progress in cancer treatment, new anticancer therapeutics drugs with new structures and/or mechanisms are still in urgent need to tackle many key challenges. Drug repurposing is a feasible strategy in discovering new drugs among the approved drugs by defining new indications. Recently, ropivacaine, a local anesthetic that has been applied in clinical practice for several decades, has been found to possess inhibitory activity and sensitizing effects when combined with conventional chemotherapeutics toward cancer cells. While its full applications and the exact targets remain to be revealed, it has been indicated that its anticancer potency was mediated by multiple mechanisms, such as modulating sodium channel, inducing mitochondria-associated apoptosis, cell cycle arrest, inhibiting autophagy, and/or regulating other key players in cancer cells, which can be termed as multi-targets/functions that require more in-depth studies. In this review, we attempted to summarize the research past decade of using ropivacaine in suppressing cancer growth and sensitizing anticancer drugs both in-vitro and in-vivo, and tried to interpret the underlying action modes. The information gained in these findings may inspire multidisciplinary efforts to develop/discover more novel anticancer agents via drug repurposing.
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spelling pubmed-88514182022-02-18 Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers Xu, Peng Zhang, Shaobo Tan, Lili Wang, Lei Yang, Zhongwei Li, Jinbao Front Oncol Oncology Despite the significant progress in cancer treatment, new anticancer therapeutics drugs with new structures and/or mechanisms are still in urgent need to tackle many key challenges. Drug repurposing is a feasible strategy in discovering new drugs among the approved drugs by defining new indications. Recently, ropivacaine, a local anesthetic that has been applied in clinical practice for several decades, has been found to possess inhibitory activity and sensitizing effects when combined with conventional chemotherapeutics toward cancer cells. While its full applications and the exact targets remain to be revealed, it has been indicated that its anticancer potency was mediated by multiple mechanisms, such as modulating sodium channel, inducing mitochondria-associated apoptosis, cell cycle arrest, inhibiting autophagy, and/or regulating other key players in cancer cells, which can be termed as multi-targets/functions that require more in-depth studies. In this review, we attempted to summarize the research past decade of using ropivacaine in suppressing cancer growth and sensitizing anticancer drugs both in-vitro and in-vivo, and tried to interpret the underlying action modes. The information gained in these findings may inspire multidisciplinary efforts to develop/discover more novel anticancer agents via drug repurposing. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8851418/ /pubmed/35186766 http://dx.doi.org/10.3389/fonc.2022.836882 Text en Copyright © 2022 Xu, Zhang, Tan, Wang, Yang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xu, Peng
Zhang, Shaobo
Tan, Lili
Wang, Lei
Yang, Zhongwei
Li, Jinbao
Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers
title Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers
title_full Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers
title_fullStr Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers
title_full_unstemmed Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers
title_short Local Anesthetic Ropivacaine Exhibits Therapeutic Effects in Cancers
title_sort local anesthetic ropivacaine exhibits therapeutic effects in cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851418/
https://www.ncbi.nlm.nih.gov/pubmed/35186766
http://dx.doi.org/10.3389/fonc.2022.836882
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