CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Foxp3-expressing CD25(+)CD4(+) regulatory T cells (Tregs) are abundant in tumor tissues. Here, hypothesizing that tumor Tregs would clonally expand after they are activated by tumor-associated antigens to suppress antitumor immune responses, we performed single-cell analysis on tumor Tregs to charac...

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Detalles Bibliográficos
Autores principales: Kidani, Yujiro, Nogami, Wataru, Yasumizu, Yoshiaki, Kawashima, Atsunari, Tanaka, Atsushi, Sonoda, Yudai, Tona, Yumi, Nashiki, Kunitaka, Matsumoto, Reimi, Hagiwara, Masaki, Osaki, Motonao, Dohi, Keiji, Kanazawa, Takayuki, Ueyama, Azumi, Yoshikawa, Mai, Yoshida, Tetsuya, Matsumoto, Mitsunobu, Hojo, Kanji, Shinonome, Satomi, Yoshida, Hiroshi, Hirata, Michinari, Haruna, Miya, Nakamura, Yamami, Motooka, Daisuke, Okuzaki, Daisuke, Sugiyama, Yasuko, Kinoshita, Makoto, Okuno, Tatsusada, Kato, Taigo, Hatano, Koji, Uemura, Motohide, Imamura, Ryoichi, Yokoi, Kazunori, Tanemura, Atsushi, Shintani, Yasushi, Kimura, Tadashi, Nonomura, Norio, Wada, Hisashi, Mori, Masaki, Doki, Yuichiro, Ohkura, Naganari, Sakaguchi, Shimon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851483/
https://www.ncbi.nlm.nih.gov/pubmed/35140181
http://dx.doi.org/10.1073/pnas.2114282119

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