The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure

The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP) primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate motor protein motility, and participate in signaling cascades. Tau misregulation and point mutations are linked to neu...

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Detalles Bibliográficos
Autores principales: Cario, Alisa, Savastano, Adriana, Wood, Neil B., Liu, Zhu, Previs, Michael J., Hendricks, Adam G., Zweckstetter, Markus, Berger, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851524/
https://www.ncbi.nlm.nih.gov/pubmed/35135879
http://dx.doi.org/10.1073/pnas.2114215119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851524/
https://www.ncbi.nlm.nih.gov/pubmed/35135879
http://dx.doi.org/10.1073/pnas.2114215119

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