Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P(2) and rapamycin

Transient receptor potential mucolipin 1 (TRPML1) is a Ca(2+)-permeable, nonselective cation channel ubiquitously expressed in the endolysosomes of mammalian cells and its loss-of-function mutations are the direct cause of type IV mucolipidosis (MLIV), an autosomal recessive lysosomal storage diseas...

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Detalles Bibliográficos
Autores principales: Gan, Ninghai, Han, Yan, Zeng, Weizhong, Wang, Yan, Xue, Jing, Jiang, Youxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851561/
https://www.ncbi.nlm.nih.gov/pubmed/35131932
http://dx.doi.org/10.1073/pnas.2120404119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851561/
https://www.ncbi.nlm.nih.gov/pubmed/35131932
http://dx.doi.org/10.1073/pnas.2120404119

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