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Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P(2) and rapamycin
Transient receptor potential mucolipin 1 (TRPML1) is a Ca(2+)-permeable, nonselective cation channel ubiquitously expressed in the endolysosomes of mammalian cells and its loss-of-function mutations are the direct cause of type IV mucolipidosis (MLIV), an autosomal recessive lysosomal storage diseas...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851561/ https://www.ncbi.nlm.nih.gov/pubmed/35131932 http://dx.doi.org/10.1073/pnas.2120404119 |