Cargando…

Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic

[Image: see text] Exposure to nerve agents, which are usually colorless and odorless gases, may cause organ failure, paralysis, or even quick death. Diethyl chlorophosphate (DCP) has been recognized as one of the most well-known chemical warfare nerve agent mimics. In the current study, we introduce...

Descripción completa

Detalles Bibliográficos
Autores principales: Alnoman, Rua B., Al-Qahtani, Salhah D., Bayazeed, Abrar, Munshi, Alaa M., Alsoliemy, Amerah, Alqarni, Sara A., El-Metwaly, Nashwa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851614/
https://www.ncbi.nlm.nih.gov/pubmed/35187374
http://dx.doi.org/10.1021/acsomega.1c07198
_version_ 1784652857000067072
author Alnoman, Rua B.
Al-Qahtani, Salhah D.
Bayazeed, Abrar
Munshi, Alaa M.
Alsoliemy, Amerah
Alqarni, Sara A.
El-Metwaly, Nashwa M.
author_facet Alnoman, Rua B.
Al-Qahtani, Salhah D.
Bayazeed, Abrar
Munshi, Alaa M.
Alsoliemy, Amerah
Alqarni, Sara A.
El-Metwaly, Nashwa M.
author_sort Alnoman, Rua B.
collection PubMed
description [Image: see text] Exposure to nerve agents, which are usually colorless and odorless gases, may cause organ failure, paralysis, or even quick death. Diethyl chlorophosphate (DCP) has been recognized as one of the most well-known chemical warfare nerve agent mimics. In the current study, we introduce a simple strategy for the development of a portable and reversible nanocomposite-based microporous strip for naked-eye detection of DCP within a few seconds. A dicyanomethylenedihydrofuran hydrazone (DCDHF-H) chromophore was synthesized by an easy azo-coupling reaction and encapsulated in situ during the preparation of cellulose acetate/cellulose nanowhisker/hydrazone (CA-CNW-H) nanocomposites. These CA-CNW-H nanocomposites displayed a bathochromic shift in the absorption intensity of about 142 nm from 438 to 580 nm with the increase of the DCP concentration. The present CA-CNW-H sensor strip displayed a detection limit for DCP ranging from 25 to 200 ppm. The color change of CA-CNW-H from yellow to purple due to exposure to DCP was detected by CIE Lab analysis. The morphology, fibrous crystallinity, thermal stability, and mechanical properties of the prepared CA-CNW-H sensor strips were investigated.
format Online
Article
Text
id pubmed-8851614
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-88516142022-02-18 Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic Alnoman, Rua B. Al-Qahtani, Salhah D. Bayazeed, Abrar Munshi, Alaa M. Alsoliemy, Amerah Alqarni, Sara A. El-Metwaly, Nashwa M. ACS Omega [Image: see text] Exposure to nerve agents, which are usually colorless and odorless gases, may cause organ failure, paralysis, or even quick death. Diethyl chlorophosphate (DCP) has been recognized as one of the most well-known chemical warfare nerve agent mimics. In the current study, we introduce a simple strategy for the development of a portable and reversible nanocomposite-based microporous strip for naked-eye detection of DCP within a few seconds. A dicyanomethylenedihydrofuran hydrazone (DCDHF-H) chromophore was synthesized by an easy azo-coupling reaction and encapsulated in situ during the preparation of cellulose acetate/cellulose nanowhisker/hydrazone (CA-CNW-H) nanocomposites. These CA-CNW-H nanocomposites displayed a bathochromic shift in the absorption intensity of about 142 nm from 438 to 580 nm with the increase of the DCP concentration. The present CA-CNW-H sensor strip displayed a detection limit for DCP ranging from 25 to 200 ppm. The color change of CA-CNW-H from yellow to purple due to exposure to DCP was detected by CIE Lab analysis. The morphology, fibrous crystallinity, thermal stability, and mechanical properties of the prepared CA-CNW-H sensor strips were investigated. American Chemical Society 2022-02-02 /pmc/articles/PMC8851614/ /pubmed/35187374 http://dx.doi.org/10.1021/acsomega.1c07198 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Alnoman, Rua B.
Al-Qahtani, Salhah D.
Bayazeed, Abrar
Munshi, Alaa M.
Alsoliemy, Amerah
Alqarni, Sara A.
El-Metwaly, Nashwa M.
Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic
title Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic
title_full Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic
title_fullStr Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic
title_full_unstemmed Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic
title_short Cellulose Acetate–Cellulose Nanowhisker Nanocomposite Immobilized with a DCDHF-Hydrazone Chromophore toward a Smart Test Strip for Colorimetric Detection of Diethyl Chlorophosphate as a Nerve Agent Mimic
title_sort cellulose acetate–cellulose nanowhisker nanocomposite immobilized with a dcdhf-hydrazone chromophore toward a smart test strip for colorimetric detection of diethyl chlorophosphate as a nerve agent mimic
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851614/
https://www.ncbi.nlm.nih.gov/pubmed/35187374
http://dx.doi.org/10.1021/acsomega.1c07198
work_keys_str_mv AT alnomanruab celluloseacetatecellulosenanowhiskernanocompositeimmobilizedwithadcdhfhydrazonechromophoretowardasmartteststripforcolorimetricdetectionofdiethylchlorophosphateasanerveagentmimic
AT alqahtanisalhahd celluloseacetatecellulosenanowhiskernanocompositeimmobilizedwithadcdhfhydrazonechromophoretowardasmartteststripforcolorimetricdetectionofdiethylchlorophosphateasanerveagentmimic
AT bayazeedabrar celluloseacetatecellulosenanowhiskernanocompositeimmobilizedwithadcdhfhydrazonechromophoretowardasmartteststripforcolorimetricdetectionofdiethylchlorophosphateasanerveagentmimic
AT munshialaam celluloseacetatecellulosenanowhiskernanocompositeimmobilizedwithadcdhfhydrazonechromophoretowardasmartteststripforcolorimetricdetectionofdiethylchlorophosphateasanerveagentmimic
AT alsoliemyamerah celluloseacetatecellulosenanowhiskernanocompositeimmobilizedwithadcdhfhydrazonechromophoretowardasmartteststripforcolorimetricdetectionofdiethylchlorophosphateasanerveagentmimic
AT alqarnisaraa celluloseacetatecellulosenanowhiskernanocompositeimmobilizedwithadcdhfhydrazonechromophoretowardasmartteststripforcolorimetricdetectionofdiethylchlorophosphateasanerveagentmimic
AT elmetwalynashwam celluloseacetatecellulosenanowhiskernanocompositeimmobilizedwithadcdhfhydrazonechromophoretowardasmartteststripforcolorimetricdetectionofdiethylchlorophosphateasanerveagentmimic