Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones

[Image: see text] A copper-mediated decarboxylative coupling reaction of 3-indoleacetic acids with pyrazolones was described. This protocol realized new functionalization of pyrazolones under simple reaction conditions and exhibited high functional group compatibility and broad substrate scope. Nota...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Kangmei, Wu, Yinrong, Chen, Jiewen, Shi, Jie, Zheng, Mulin, Yao, Xingang, Tang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851627/
https://www.ncbi.nlm.nih.gov/pubmed/35187342
http://dx.doi.org/10.1021/acsomega.1c06443
_version_ 1784652859910914048
author Wen, Kangmei
Wu, Yinrong
Chen, Jiewen
Shi, Jie
Zheng, Mulin
Yao, Xingang
Tang, Xiaodong
author_facet Wen, Kangmei
Wu, Yinrong
Chen, Jiewen
Shi, Jie
Zheng, Mulin
Yao, Xingang
Tang, Xiaodong
author_sort Wen, Kangmei
collection PubMed
description [Image: see text] A copper-mediated decarboxylative coupling reaction of 3-indoleacetic acids with pyrazolones was described. This protocol realized new functionalization of pyrazolones under simple reaction conditions and exhibited high functional group compatibility and broad substrate scope. Notably, the products displayed antiproliferative activity against cancer cells.
format Online
Article
Text
id pubmed-8851627
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-88516272022-02-18 Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones Wen, Kangmei Wu, Yinrong Chen, Jiewen Shi, Jie Zheng, Mulin Yao, Xingang Tang, Xiaodong ACS Omega [Image: see text] A copper-mediated decarboxylative coupling reaction of 3-indoleacetic acids with pyrazolones was described. This protocol realized new functionalization of pyrazolones under simple reaction conditions and exhibited high functional group compatibility and broad substrate scope. Notably, the products displayed antiproliferative activity against cancer cells. American Chemical Society 2022-02-02 /pmc/articles/PMC8851627/ /pubmed/35187342 http://dx.doi.org/10.1021/acsomega.1c06443 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wen, Kangmei
Wu, Yinrong
Chen, Jiewen
Shi, Jie
Zheng, Mulin
Yao, Xingang
Tang, Xiaodong
Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones
title Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones
title_full Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones
title_fullStr Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones
title_full_unstemmed Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones
title_short Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Pyrazolones
title_sort copper-mediated decarboxylative coupling of 3-indoleacetic acids with pyrazolones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851627/
https://www.ncbi.nlm.nih.gov/pubmed/35187342
http://dx.doi.org/10.1021/acsomega.1c06443
work_keys_str_mv AT wenkangmei coppermediateddecarboxylativecouplingof3indoleaceticacidswithpyrazolones
AT wuyinrong coppermediateddecarboxylativecouplingof3indoleaceticacidswithpyrazolones
AT chenjiewen coppermediateddecarboxylativecouplingof3indoleaceticacidswithpyrazolones
AT shijie coppermediateddecarboxylativecouplingof3indoleaceticacidswithpyrazolones
AT zhengmulin coppermediateddecarboxylativecouplingof3indoleaceticacidswithpyrazolones
AT yaoxingang coppermediateddecarboxylativecouplingof3indoleaceticacidswithpyrazolones
AT tangxiaodong coppermediateddecarboxylativecouplingof3indoleaceticacidswithpyrazolones

Ejemplares similares