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Global prevalence and burden of meal-related abdominal pain

BACKGROUND: Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcomes, but this subgroup has not been well characterized. We aimed to describe the...

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Main Authors: Colomier, Esther, Melchior, Chloé, Algera, Joost P., Hreinsson, Jóhann P., Störsrud, Stine, Törnblom, Hans, Van Oudenhove, Lukas, Palsson, Olafur S., Bangdiwala, Shrikant I., Sperber, Ami D., Tack, Jan, Simrén, Magnus
Format: Online Article Text
Language:English
Published: BioMed Central 2022
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851773/
https://www.ncbi.nlm.nih.gov/pubmed/35172840
http://dx.doi.org/10.1186/s12916-022-02259-7
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author Colomier, Esther
Melchior, Chloé
Algera, Joost P.
Hreinsson, Jóhann P.
Störsrud, Stine
Törnblom, Hans
Van Oudenhove, Lukas
Palsson, Olafur S.
Bangdiwala, Shrikant I.
Sperber, Ami D.
Tack, Jan
Simrén, Magnus
author_facet Colomier, Esther
Melchior, Chloé
Algera, Joost P.
Hreinsson, Jóhann P.
Störsrud, Stine
Törnblom, Hans
Van Oudenhove, Lukas
Palsson, Olafur S.
Bangdiwala, Shrikant I.
Sperber, Ami D.
Tack, Jan
Simrén, Magnus
author_sort Colomier, Esther
collection PubMed
description BACKGROUND: Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcomes, but this subgroup has not been well characterized. We aimed to describe the global prevalence of meal-related abdominal pain and characterize this subgroup. METHODS: The data analyzed originated from the Internet survey component of the population-based Rome Foundation Global Epidemiology Study, completed in 26 countries (n = 54,127). Adult subjects were asked whether they had abdominal pain and how often this was meal-related. Respondents were categorized into “no,” “occasional,” and “frequent” meal-related abdominal pain groups based on 0%, 10–40%, and ≥50% of the pain episodes being meal-related, respectively. DGBI diagnoses, frequency of other GI symptoms, psychological distress, non-GI somatic symptoms, quality of life, and healthcare utilization were compared between groups. Mixed linear and ordinal regression was used to assess independent associations between psychological distress, non-GI somatic symptoms, quality of life, other GI symptoms, and meal-related abdominal pain. RESULTS: Overall, 51.9% of the respondents reported abdominal pain in the last 3 months, and 11.0% belonged to the group with frequent meal-related abdominal pain, which included more females and younger subjects. DGBI diagnoses were more common in subjects with frequent meal-related abdominal pain, and the frequency of several GI symptoms was associated with having more frequent meal-related abdominal pain. Having meal-related abdominal pain more frequently was also associated with more severe psychological distress, non-GI somatic symptoms, and a poorer quality of life. The group with frequent meal-related abdominal pain also more often consulted a doctor for bowel problems compared to the other groups of meal-related abdominal pain. CONCLUSION: Reporting frequent meal-related abdominal pain is common across the globe and associated with other GI and non-GI somatic symptoms, psychological distress, healthcare utilization, and a poorer quality of life. Individuals who frequently experience meal-related abdominal pain also more frequently fulfill the diagnostic criteria for DGBI. Assessing meal-related symptoms in all DGBI patients could be of major importance to improve and individualize symptom management. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02259-7.
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spelling pubmed-88517732022-02-22 Global prevalence and burden of meal-related abdominal pain Colomier, Esther Melchior, Chloé Algera, Joost P. Hreinsson, Jóhann P. Störsrud, Stine Törnblom, Hans Van Oudenhove, Lukas Palsson, Olafur S. Bangdiwala, Shrikant I. Sperber, Ami D. Tack, Jan Simrén, Magnus BMC Med Research Article BACKGROUND: Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcomes, but this subgroup has not been well characterized. We aimed to describe the global prevalence of meal-related abdominal pain and characterize this subgroup. METHODS: The data analyzed originated from the Internet survey component of the population-based Rome Foundation Global Epidemiology Study, completed in 26 countries (n = 54,127). Adult subjects were asked whether they had abdominal pain and how often this was meal-related. Respondents were categorized into “no,” “occasional,” and “frequent” meal-related abdominal pain groups based on 0%, 10–40%, and ≥50% of the pain episodes being meal-related, respectively. DGBI diagnoses, frequency of other GI symptoms, psychological distress, non-GI somatic symptoms, quality of life, and healthcare utilization were compared between groups. Mixed linear and ordinal regression was used to assess independent associations between psychological distress, non-GI somatic symptoms, quality of life, other GI symptoms, and meal-related abdominal pain. RESULTS: Overall, 51.9% of the respondents reported abdominal pain in the last 3 months, and 11.0% belonged to the group with frequent meal-related abdominal pain, which included more females and younger subjects. DGBI diagnoses were more common in subjects with frequent meal-related abdominal pain, and the frequency of several GI symptoms was associated with having more frequent meal-related abdominal pain. Having meal-related abdominal pain more frequently was also associated with more severe psychological distress, non-GI somatic symptoms, and a poorer quality of life. The group with frequent meal-related abdominal pain also more often consulted a doctor for bowel problems compared to the other groups of meal-related abdominal pain. CONCLUSION: Reporting frequent meal-related abdominal pain is common across the globe and associated with other GI and non-GI somatic symptoms, psychological distress, healthcare utilization, and a poorer quality of life. Individuals who frequently experience meal-related abdominal pain also more frequently fulfill the diagnostic criteria for DGBI. Assessing meal-related symptoms in all DGBI patients could be of major importance to improve and individualize symptom management. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02259-7. BioMed Central 2022-02-17 /pmc/articles/PMC8851773/ /pubmed/35172840 http://dx.doi.org/10.1186/s12916-022-02259-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Colomier, Esther
Melchior, Chloé
Algera, Joost P.
Hreinsson, Jóhann P.
Störsrud, Stine
Törnblom, Hans
Van Oudenhove, Lukas
Palsson, Olafur S.
Bangdiwala, Shrikant I.
Sperber, Ami D.
Tack, Jan
Simrén, Magnus
Global prevalence and burden of meal-related abdominal pain
title Global prevalence and burden of meal-related abdominal pain
title_full Global prevalence and burden of meal-related abdominal pain
title_fullStr Global prevalence and burden of meal-related abdominal pain
title_full_unstemmed Global prevalence and burden of meal-related abdominal pain
title_short Global prevalence and burden of meal-related abdominal pain
title_sort global prevalence and burden of meal-related abdominal pain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851773/
https://www.ncbi.nlm.nih.gov/pubmed/35172840
http://dx.doi.org/10.1186/s12916-022-02259-7
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