NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation

Transgenic expression of bacterial nitroreductase (NTR) enzymes sensitizes eukaryotic cells to prodrugs such as metronidazole (MTZ), enabling selective cell ablation paradigms that have expanded studies of cell function and regeneration in vertebrates. However, first-generation NTRs required confoun...

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Detalles Bibliográficos
Autores principales: Sharrock, Abigail V., Mulligan, Timothy S., Hall, Kelsi R., Williams, Elsie M., White, David T., Zhang, Liyun, Emmerich, Kevin, Matthews, Frazer, Nimmagadda, Saumya, Washington, Selena, Le, Katherine D., Meir-Levi, Danielle, Cox, Olivia L., Saxena, Meera T., Calof, Anne L., Lopez-Burks, Martha E., Lander, Arthur D., Ding, Ding, Ji, Hongkai, Ackerley, David F., Mumm, Jeff S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851868/
https://www.ncbi.nlm.nih.gov/pubmed/35132245
http://dx.doi.org/10.1038/s41592-021-01364-4

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