A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4

To date, the direct causative mechanism of SARS-CoV-2-induced endotheliitis remains unclear. Here, we report that human ECs barely express surface ACE2, and ECs express less intracellular ACE2 than non-ECs of the lungs. We ectopically expressed ACE2 in hESC-ECs to model SARS-CoV-2 infection. ACE2-de...

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Detalles Bibliográficos
Autores principales: Ma, Zhangjing, Li, Xisheng, Fan, Rebecca L.Y., Yang, Kevin Y., Ng, Calvin S.H., Lau, Rainbow W.H., Wong, Randolph H.L., Ng, Kevin K., Wang, Chi Chiu, Ye, Peng, Fu, Zelong, Chin, Alex W.H., Lai, M.Y. Alison, Huang, Yu, Tian, Xiao Yu, Poon, Leo L.M., Lui, Kathy O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851885/
https://www.ncbi.nlm.nih.gov/pubmed/35180397
http://dx.doi.org/10.1016/j.stemcr.2022.01.015

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