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Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG Alzheimer's disease mice

Histone acetylation, catalyzed by histone acetyltransferases, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF...

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Detalles Bibliográficos
Autores principales:	Creighton, Samantha D., Jardine, Kristen H., Desimone, Alexa, Zmetana, Megan, Castellano, Sabrina, Milite, Ciro, Sbardella, Gianluca, Winters, Boyer D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852226/ https://www.ncbi.nlm.nih.gov/pubmed/35169045 http://dx.doi.org/10.1101/lm.053536.121

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