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Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter

Detection of liver dysfunction in patients with diffuse toxic goiter (DTG) at an early stage allows for correcting it in time with appropriate therapy; therefore, diagnosing hepatobiliary system lesions in these patients is an important medical issue. We examined 62 patients, divided into two groups...

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Autores principales: Lavruk, Khrystyna Zynoviivna, Dudiy, Petro Fedorovych, Skrypnyk, Nadiya Vasylivna, Mishchuk, Vasyl Hryhorovych, Vytvytskiy, Zynoviy Yaroslavovych
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852630/
https://www.ncbi.nlm.nih.gov/pubmed/35186140
http://dx.doi.org/10.25122/jml-2021-0291
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author Lavruk, Khrystyna Zynoviivna
Dudiy, Petro Fedorovych
Skrypnyk, Nadiya Vasylivna
Mishchuk, Vasyl Hryhorovych
Vytvytskiy, Zynoviy Yaroslavovych
author_facet Lavruk, Khrystyna Zynoviivna
Dudiy, Petro Fedorovych
Skrypnyk, Nadiya Vasylivna
Mishchuk, Vasyl Hryhorovych
Vytvytskiy, Zynoviy Yaroslavovych
author_sort Lavruk, Khrystyna Zynoviivna
collection PubMed
description Detection of liver dysfunction in patients with diffuse toxic goiter (DTG) at an early stage allows for correcting it in time with appropriate therapy; therefore, diagnosing hepatobiliary system lesions in these patients is an important medical issue. We examined 62 patients, divided into two groups depending on the duration of the disease. The first group included patients with a disease duration of up to two years, the second group - patients with a disease duration of more than two years. The study and comparison of laboratory and multiparametric ultrasound criteria of liver and thyroid dysfunction were performed. Analysis of ultrasound signs of hepatobiliary system lesions in patients in the two groups showed that they were more common in the second group. There is a correlation between the stiffness of the parenchyma of the thyroid gland and liver and the duration of the disease, the level of free thyroxine (T4f), and antibodies to thyroid-stimulating hormone receptors (ArTTG). Increased liver stiffness was more common in patients with ArTTG levels above 20 IU/ml, and the degree of F1 fibrosis was higher at T4f greater than 50 pmol/l. To assess the condition of a patient with DTG and the need to correct treatment tactics, it is advisable to use the criteria of multiparametric ultrasound examination of the hepatobiliary system and thyroid gland.
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spelling pubmed-88526302022-03-01 Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter Lavruk, Khrystyna Zynoviivna Dudiy, Petro Fedorovych Skrypnyk, Nadiya Vasylivna Mishchuk, Vasyl Hryhorovych Vytvytskiy, Zynoviy Yaroslavovych J Med Life Original Article Detection of liver dysfunction in patients with diffuse toxic goiter (DTG) at an early stage allows for correcting it in time with appropriate therapy; therefore, diagnosing hepatobiliary system lesions in these patients is an important medical issue. We examined 62 patients, divided into two groups depending on the duration of the disease. The first group included patients with a disease duration of up to two years, the second group - patients with a disease duration of more than two years. The study and comparison of laboratory and multiparametric ultrasound criteria of liver and thyroid dysfunction were performed. Analysis of ultrasound signs of hepatobiliary system lesions in patients in the two groups showed that they were more common in the second group. There is a correlation between the stiffness of the parenchyma of the thyroid gland and liver and the duration of the disease, the level of free thyroxine (T4f), and antibodies to thyroid-stimulating hormone receptors (ArTTG). Increased liver stiffness was more common in patients with ArTTG levels above 20 IU/ml, and the degree of F1 fibrosis was higher at T4f greater than 50 pmol/l. To assess the condition of a patient with DTG and the need to correct treatment tactics, it is advisable to use the criteria of multiparametric ultrasound examination of the hepatobiliary system and thyroid gland. Carol Davila University Press 2022-01 /pmc/articles/PMC8852630/ /pubmed/35186140 http://dx.doi.org/10.25122/jml-2021-0291 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Lavruk, Khrystyna Zynoviivna
Dudiy, Petro Fedorovych
Skrypnyk, Nadiya Vasylivna
Mishchuk, Vasyl Hryhorovych
Vytvytskiy, Zynoviy Yaroslavovych
Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter
title Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter
title_full Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter
title_fullStr Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter
title_full_unstemmed Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter
title_short Clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter
title_sort clinical-laboratory and ultrasound parallels of changes in the liver and thyroid gland in diffuse toxic goiter
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852630/
https://www.ncbi.nlm.nih.gov/pubmed/35186140
http://dx.doi.org/10.25122/jml-2021-0291
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