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Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
Tumour necrosis factor (TNF)-α plays an important role in inflammatory, infectious, and tumor processes, and it is closely related to the early stages of gastric cancer. It is a pro-inflammatory cytokine, produced not only by macrophages and monocytes but also by the lymphocytes, mast cells, neutrop...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Carol Davila University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852641/ https://www.ncbi.nlm.nih.gov/pubmed/35186129 http://dx.doi.org/10.25122/jml-2020-0098 |
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author | Roșu, Mihai Cătălin Mihnea, Petrut Dinu Ardelean, Andrei Moldovan, Silviu Daniel Popețiu, Romana Olivia Totolici, Bogdan Dan |
author_facet | Roșu, Mihai Cătălin Mihnea, Petrut Dinu Ardelean, Andrei Moldovan, Silviu Daniel Popețiu, Romana Olivia Totolici, Bogdan Dan |
author_sort | Roșu, Mihai Cătălin |
collection | PubMed |
description | Tumour necrosis factor (TNF)-α plays an important role in inflammatory, infectious, and tumor processes, and it is closely related to the early stages of gastric cancer. It is a pro-inflammatory cytokine, produced not only by macrophages and monocytes but also by the lymphocytes, mast cells, neutrophils, keratinocytes, smooth muscle cells, and some tumor cell lines. Large amounts of TNF are released upon contact of macrophages, CD4 + T lymphocytes, and natural killer (NK) cells with lipopolysaccharides, bacterial products, and interleukin 1. TNF-alpha inducing protein (Tipa) is a unique carcinogenic factor of Helicobacter pylori, secreted into culture broth. The biological activities of TNF alpha and deletion mutant were studied. TNF alpha protein specifically binds to cell-surface nucleolin and then enters the gastric cancer cells, where TNF-a and chemokine gene expressions are induced by NF-jB activation. Nucleolin localizes on the surface of gastric cancer cells, and interaction between TNF alpha and cell-surface nucleolin causes a cancer-oriented microenvironment that increases the risk of gastric cancer. This paper discusses a mechanism of gastric cancer development and the clinical significance of tumor necrosis-alpha and carcinoembryonic antigen in gastric cancer. |
format | Online Article Text |
id | pubmed-8852641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88526412022-03-01 Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer Roșu, Mihai Cătălin Mihnea, Petrut Dinu Ardelean, Andrei Moldovan, Silviu Daniel Popețiu, Romana Olivia Totolici, Bogdan Dan J Med Life Review Tumour necrosis factor (TNF)-α plays an important role in inflammatory, infectious, and tumor processes, and it is closely related to the early stages of gastric cancer. It is a pro-inflammatory cytokine, produced not only by macrophages and monocytes but also by the lymphocytes, mast cells, neutrophils, keratinocytes, smooth muscle cells, and some tumor cell lines. Large amounts of TNF are released upon contact of macrophages, CD4 + T lymphocytes, and natural killer (NK) cells with lipopolysaccharides, bacterial products, and interleukin 1. TNF-alpha inducing protein (Tipa) is a unique carcinogenic factor of Helicobacter pylori, secreted into culture broth. The biological activities of TNF alpha and deletion mutant were studied. TNF alpha protein specifically binds to cell-surface nucleolin and then enters the gastric cancer cells, where TNF-a and chemokine gene expressions are induced by NF-jB activation. Nucleolin localizes on the surface of gastric cancer cells, and interaction between TNF alpha and cell-surface nucleolin causes a cancer-oriented microenvironment that increases the risk of gastric cancer. This paper discusses a mechanism of gastric cancer development and the clinical significance of tumor necrosis-alpha and carcinoembryonic antigen in gastric cancer. Carol Davila University Press 2022-01 /pmc/articles/PMC8852641/ /pubmed/35186129 http://dx.doi.org/10.25122/jml-2020-0098 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Review Roșu, Mihai Cătălin Mihnea, Petrut Dinu Ardelean, Andrei Moldovan, Silviu Daniel Popețiu, Romana Olivia Totolici, Bogdan Dan Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer |
title | Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer |
title_full | Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer |
title_fullStr | Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer |
title_full_unstemmed | Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer |
title_short | Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer |
title_sort | clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852641/ https://www.ncbi.nlm.nih.gov/pubmed/35186129 http://dx.doi.org/10.25122/jml-2020-0098 |
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