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Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer

Tumour necrosis factor (TNF)-α plays an important role in inflammatory, infectious, and tumor processes, and it is closely related to the early stages of gastric cancer. It is a pro-inflammatory cytokine, produced not only by macrophages and monocytes but also by the lymphocytes, mast cells, neutrop...

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Autores principales: Roșu, Mihai Cătălin, Mihnea, Petrut Dinu, Ardelean, Andrei, Moldovan, Silviu Daniel, Popețiu, Romana Olivia, Totolici, Bogdan Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852641/
https://www.ncbi.nlm.nih.gov/pubmed/35186129
http://dx.doi.org/10.25122/jml-2020-0098
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author Roșu, Mihai Cătălin
Mihnea, Petrut Dinu
Ardelean, Andrei
Moldovan, Silviu Daniel
Popețiu, Romana Olivia
Totolici, Bogdan Dan
author_facet Roșu, Mihai Cătălin
Mihnea, Petrut Dinu
Ardelean, Andrei
Moldovan, Silviu Daniel
Popețiu, Romana Olivia
Totolici, Bogdan Dan
author_sort Roșu, Mihai Cătălin
collection PubMed
description Tumour necrosis factor (TNF)-α plays an important role in inflammatory, infectious, and tumor processes, and it is closely related to the early stages of gastric cancer. It is a pro-inflammatory cytokine, produced not only by macrophages and monocytes but also by the lymphocytes, mast cells, neutrophils, keratinocytes, smooth muscle cells, and some tumor cell lines. Large amounts of TNF are released upon contact of macrophages, CD4 + T lymphocytes, and natural killer (NK) cells with lipopolysaccharides, bacterial products, and interleukin 1. TNF-alpha inducing protein (Tipa) is a unique carcinogenic factor of Helicobacter pylori, secreted into culture broth. The biological activities of TNF alpha and deletion mutant were studied. TNF alpha protein specifically binds to cell-surface nucleolin and then enters the gastric cancer cells, where TNF-a and chemokine gene expressions are induced by NF-jB activation. Nucleolin localizes on the surface of gastric cancer cells, and interaction between TNF alpha and cell-surface nucleolin causes a cancer-oriented microenvironment that increases the risk of gastric cancer. This paper discusses a mechanism of gastric cancer development and the clinical significance of tumor necrosis-alpha and carcinoembryonic antigen in gastric cancer.
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spelling pubmed-88526412022-03-01 Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer Roșu, Mihai Cătălin Mihnea, Petrut Dinu Ardelean, Andrei Moldovan, Silviu Daniel Popețiu, Romana Olivia Totolici, Bogdan Dan J Med Life Review Tumour necrosis factor (TNF)-α plays an important role in inflammatory, infectious, and tumor processes, and it is closely related to the early stages of gastric cancer. It is a pro-inflammatory cytokine, produced not only by macrophages and monocytes but also by the lymphocytes, mast cells, neutrophils, keratinocytes, smooth muscle cells, and some tumor cell lines. Large amounts of TNF are released upon contact of macrophages, CD4 + T lymphocytes, and natural killer (NK) cells with lipopolysaccharides, bacterial products, and interleukin 1. TNF-alpha inducing protein (Tipa) is a unique carcinogenic factor of Helicobacter pylori, secreted into culture broth. The biological activities of TNF alpha and deletion mutant were studied. TNF alpha protein specifically binds to cell-surface nucleolin and then enters the gastric cancer cells, where TNF-a and chemokine gene expressions are induced by NF-jB activation. Nucleolin localizes on the surface of gastric cancer cells, and interaction between TNF alpha and cell-surface nucleolin causes a cancer-oriented microenvironment that increases the risk of gastric cancer. This paper discusses a mechanism of gastric cancer development and the clinical significance of tumor necrosis-alpha and carcinoembryonic antigen in gastric cancer. Carol Davila University Press 2022-01 /pmc/articles/PMC8852641/ /pubmed/35186129 http://dx.doi.org/10.25122/jml-2020-0098 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Roșu, Mihai Cătălin
Mihnea, Petrut Dinu
Ardelean, Andrei
Moldovan, Silviu Daniel
Popețiu, Romana Olivia
Totolici, Bogdan Dan
Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
title Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
title_full Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
title_fullStr Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
title_full_unstemmed Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
title_short Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
title_sort clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852641/
https://www.ncbi.nlm.nih.gov/pubmed/35186129
http://dx.doi.org/10.25122/jml-2020-0098
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