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Cytomegalovirus infection after renal transplantation

Renal transplant patients show a high prevalence of cytomegalovirus (CMV) infection after the procedure. This study was conducted to assess the prevalence and factors associated with the incidence of CMV infection among renal transplant patients. A total of 100 patients were recruited in this study....

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Autores principales: Al Atbee, Mohammed Younus Naji, Tuama, Hala Sami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852648/
https://www.ncbi.nlm.nih.gov/pubmed/35186139
http://dx.doi.org/10.25122/jml-2021-0209
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author Al Atbee, Mohammed Younus Naji
Tuama, Hala Sami
author_facet Al Atbee, Mohammed Younus Naji
Tuama, Hala Sami
author_sort Al Atbee, Mohammed Younus Naji
collection PubMed
description Renal transplant patients show a high prevalence of cytomegalovirus (CMV) infection after the procedure. This study was conducted to assess the prevalence and factors associated with the incidence of CMV infection among renal transplant patients. A total of 100 patients were recruited in this study. The CMV load in the blood of each patient was assessed using the technique of polymerase chain reaction (PCR). The serostatus of all recipients and donors was examined preoperatively and those of the recipients again postoperatively. The association of CMV load was assessed with the following factors: age, gender, alanine aminotransferase (ALT) and serum creatinine levels, types of immunosuppressive and induction regimens, preoperative diabetes status, and serological virologic response (SVR) at 12 weeks postoperatively. Our findings showed that CMV incidence was significantly higher in middle-aged patients (62 of 66 patients, 93.9%; p=0.0001). Furthermore, about 88.2% of patients induced by anti-thymocyte globulin (ATG) showed a high viral load, significantly higher than the proportion of CMV-positive patients induced by basiliximab (p=0.001). In addition, a higher proportion of CMV-negative recipients who received the graft from CMV-positive donors and vice-versa were CMV-positive postoperatively. Administration of Valcyte 450 showed 100% efficiency in decreasing the CMV load in the patients. Among all the assessed factors, only the age of the recipients, type of induction therapy used, and the preoperative serostatus of both donors and recipients were significantly associated with the postoperative CMV incidence among the patients.
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spelling pubmed-88526482022-03-01 Cytomegalovirus infection after renal transplantation Al Atbee, Mohammed Younus Naji Tuama, Hala Sami J Med Life Original Article Renal transplant patients show a high prevalence of cytomegalovirus (CMV) infection after the procedure. This study was conducted to assess the prevalence and factors associated with the incidence of CMV infection among renal transplant patients. A total of 100 patients were recruited in this study. The CMV load in the blood of each patient was assessed using the technique of polymerase chain reaction (PCR). The serostatus of all recipients and donors was examined preoperatively and those of the recipients again postoperatively. The association of CMV load was assessed with the following factors: age, gender, alanine aminotransferase (ALT) and serum creatinine levels, types of immunosuppressive and induction regimens, preoperative diabetes status, and serological virologic response (SVR) at 12 weeks postoperatively. Our findings showed that CMV incidence was significantly higher in middle-aged patients (62 of 66 patients, 93.9%; p=0.0001). Furthermore, about 88.2% of patients induced by anti-thymocyte globulin (ATG) showed a high viral load, significantly higher than the proportion of CMV-positive patients induced by basiliximab (p=0.001). In addition, a higher proportion of CMV-negative recipients who received the graft from CMV-positive donors and vice-versa were CMV-positive postoperatively. Administration of Valcyte 450 showed 100% efficiency in decreasing the CMV load in the patients. Among all the assessed factors, only the age of the recipients, type of induction therapy used, and the preoperative serostatus of both donors and recipients were significantly associated with the postoperative CMV incidence among the patients. Carol Davila University Press 2022-01 /pmc/articles/PMC8852648/ /pubmed/35186139 http://dx.doi.org/10.25122/jml-2021-0209 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Al Atbee, Mohammed Younus Naji
Tuama, Hala Sami
Cytomegalovirus infection after renal transplantation
title Cytomegalovirus infection after renal transplantation
title_full Cytomegalovirus infection after renal transplantation
title_fullStr Cytomegalovirus infection after renal transplantation
title_full_unstemmed Cytomegalovirus infection after renal transplantation
title_short Cytomegalovirus infection after renal transplantation
title_sort cytomegalovirus infection after renal transplantation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852648/
https://www.ncbi.nlm.nih.gov/pubmed/35186139
http://dx.doi.org/10.25122/jml-2021-0209
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