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Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma

Growing evidence indicates a link between retinoic acid (RA) metabolism and sarcoma progression or immunity in laboratory studies. However, a comprehensive analysis of RA abnormality in the sarcoma population is still lacking. Herein, we systematically analyzed the molecular features of 19 retinoic...

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Autores principales: Xu, HuaiYuan, Hu, JinXin, Song, YiJiang, Chen, HongMin, Xu, YanYang, Deng, ChuangZhong, Wu, Hao, Song, GuoHui, Lu, JinChang, Tang, QinLian, Xia, LiangPing, Wang, Jin, Zhu, XiaoJun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852678/
https://www.ncbi.nlm.nih.gov/pubmed/35186946
http://dx.doi.org/10.3389/fcell.2021.780951
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author Xu, HuaiYuan
Hu, JinXin
Song, YiJiang
Chen, HongMin
Xu, YanYang
Deng, ChuangZhong
Wu, Hao
Song, GuoHui
Lu, JinChang
Tang, QinLian
Xia, LiangPing
Wang, Jin
Zhu, XiaoJun
author_facet Xu, HuaiYuan
Hu, JinXin
Song, YiJiang
Chen, HongMin
Xu, YanYang
Deng, ChuangZhong
Wu, Hao
Song, GuoHui
Lu, JinChang
Tang, QinLian
Xia, LiangPing
Wang, Jin
Zhu, XiaoJun
author_sort Xu, HuaiYuan
collection PubMed
description Growing evidence indicates a link between retinoic acid (RA) metabolism and sarcoma progression or immunity in laboratory studies. However, a comprehensive analysis of RA abnormality in the sarcoma population is still lacking. Herein, we systematically analyzed the molecular features of 19 retinoic acid metabolism-related enzymes and sarcoma patients’ clinical information based on TCGA/TARGET/GSE datasets. We identified two RA expression subtypes, which were related to distinct clinical survival outcomes and exhibited different biological features. Gene set enrichment analysis indicated a set of immune pathways were enriched in G1 while oncogenic pathways were enriched in G2. Immune cell infiltration analysis using the TIMER algorithm revealed more CD4(+) and CD8(+) T cell infiltration in G1 subgroups than in G2. Moreover, we generated a seven genes signature to predict the RA metabolism index based on the LASSO-penalized Cox regression model. Survival analysis demonstrated the significant prognostic differences between high- and low-risk groups among different bone and soft tissue datasets. A higher risk index was associated with less T cell CD8(+) infiltration. The predictive ability of the RA risk score was validated in 71 bone or soft tissue sarcoma clinical samples. These results indicated that RA-based classification could distinguish sarcoma patients with different clinical outcomes and immune statuses, which may help to explore better treatment decision-making for sarcoma patients.
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spelling pubmed-88526782022-02-18 Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma Xu, HuaiYuan Hu, JinXin Song, YiJiang Chen, HongMin Xu, YanYang Deng, ChuangZhong Wu, Hao Song, GuoHui Lu, JinChang Tang, QinLian Xia, LiangPing Wang, Jin Zhu, XiaoJun Front Cell Dev Biol Cell and Developmental Biology Growing evidence indicates a link between retinoic acid (RA) metabolism and sarcoma progression or immunity in laboratory studies. However, a comprehensive analysis of RA abnormality in the sarcoma population is still lacking. Herein, we systematically analyzed the molecular features of 19 retinoic acid metabolism-related enzymes and sarcoma patients’ clinical information based on TCGA/TARGET/GSE datasets. We identified two RA expression subtypes, which were related to distinct clinical survival outcomes and exhibited different biological features. Gene set enrichment analysis indicated a set of immune pathways were enriched in G1 while oncogenic pathways were enriched in G2. Immune cell infiltration analysis using the TIMER algorithm revealed more CD4(+) and CD8(+) T cell infiltration in G1 subgroups than in G2. Moreover, we generated a seven genes signature to predict the RA metabolism index based on the LASSO-penalized Cox regression model. Survival analysis demonstrated the significant prognostic differences between high- and low-risk groups among different bone and soft tissue datasets. A higher risk index was associated with less T cell CD8(+) infiltration. The predictive ability of the RA risk score was validated in 71 bone or soft tissue sarcoma clinical samples. These results indicated that RA-based classification could distinguish sarcoma patients with different clinical outcomes and immune statuses, which may help to explore better treatment decision-making for sarcoma patients. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8852678/ /pubmed/35186946 http://dx.doi.org/10.3389/fcell.2021.780951 Text en Copyright © 2022 Xu, Hu, Song, Chen, Xu, Deng, Wu, Song, Lu, Tang, Xia, Wang and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Xu, HuaiYuan
Hu, JinXin
Song, YiJiang
Chen, HongMin
Xu, YanYang
Deng, ChuangZhong
Wu, Hao
Song, GuoHui
Lu, JinChang
Tang, QinLian
Xia, LiangPing
Wang, Jin
Zhu, XiaoJun
Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma
title Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma
title_full Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma
title_fullStr Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma
title_full_unstemmed Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma
title_short Retinoic Acid Metabolism-Related Enzyme Signature Identified Prognostic and Immune Characteristics in Sarcoma
title_sort retinoic acid metabolism-related enzyme signature identified prognostic and immune characteristics in sarcoma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852678/
https://www.ncbi.nlm.nih.gov/pubmed/35186946
http://dx.doi.org/10.3389/fcell.2021.780951
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