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Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study

OBJECTIVE: To determine the association of allergic conditions with incident rheumatoid arthritis (RA), especially in relation to smoking history and anti-citrullinated peptide antibody (ACPA) status. METHODS: This case–control study included 3515 incident RA cases and 5429 matched controls from the...

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Autores principales: Kronzer, Vanessa L, Westerlind, Helga, Alfredsson, Lars, Crowson, Cynthia S, Klareskog, Lars, Holmqvist, Marie, Askling, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852704/
https://www.ncbi.nlm.nih.gov/pubmed/35168998
http://dx.doi.org/10.1136/rmdopen-2021-002018
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author Kronzer, Vanessa L
Westerlind, Helga
Alfredsson, Lars
Crowson, Cynthia S
Klareskog, Lars
Holmqvist, Marie
Askling, Johan
author_facet Kronzer, Vanessa L
Westerlind, Helga
Alfredsson, Lars
Crowson, Cynthia S
Klareskog, Lars
Holmqvist, Marie
Askling, Johan
author_sort Kronzer, Vanessa L
collection PubMed
description OBJECTIVE: To determine the association of allergic conditions with incident rheumatoid arthritis (RA), especially in relation to smoking history and anti-citrullinated peptide antibody (ACPA) status. METHODS: This case–control study included 3515 incident RA cases and 5429 matched controls from the Epidemiological Investigation of Rheumatoid Arthritis study 1995 to 2016, including questionnaire-based information on eight allergic conditions composed from a list of 59 unique allergies. We used logistic regression and adjusted ORs (aOR) to assess the association between allergic conditions and risk of RA, adjusting for age, sex, residential area, body mass index, education, and smoking, and stratified by smoking and ACPA. RESULTS: A history of any reported allergy was equally common in RA (n=1047, 30%) as among population controls (n=1540, 29%), aOR 1.04, 95% CI 0.95 to 1.15. Metal, respiratory, food, plant/pollen and chemical allergies were not associated with risk of RA. By contrast, statistically significant associations were observed for animal dander allergy (6% vs 5%, aOR 1.37, 95% CI 1.03 to 1.82), especially in ACPA-positive RA (aOR 1.46 95% CI 1.06 to 2.01) and for atopic dermatitis, in particular for older and ACPA-negative RA (aOR 2.33, 95% CI 1.37 to 3.96 at age 80). Never smokers with allergic rhinitis also had increased risk of developing RA (aOR 1.30, 95% CI 1.00 to 1.68). CONCLUSION: Most common allergies do not increase risk of RA, nor do they protect against RA. However, some allergic conditions, notably animal dander allergy, atopic dermatitis and allergic rhinitis, were associated with an increased risk for RA.
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spelling pubmed-88527042022-03-03 Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study Kronzer, Vanessa L Westerlind, Helga Alfredsson, Lars Crowson, Cynthia S Klareskog, Lars Holmqvist, Marie Askling, Johan RMD Open Inflammatory Arthritis OBJECTIVE: To determine the association of allergic conditions with incident rheumatoid arthritis (RA), especially in relation to smoking history and anti-citrullinated peptide antibody (ACPA) status. METHODS: This case–control study included 3515 incident RA cases and 5429 matched controls from the Epidemiological Investigation of Rheumatoid Arthritis study 1995 to 2016, including questionnaire-based information on eight allergic conditions composed from a list of 59 unique allergies. We used logistic regression and adjusted ORs (aOR) to assess the association between allergic conditions and risk of RA, adjusting for age, sex, residential area, body mass index, education, and smoking, and stratified by smoking and ACPA. RESULTS: A history of any reported allergy was equally common in RA (n=1047, 30%) as among population controls (n=1540, 29%), aOR 1.04, 95% CI 0.95 to 1.15. Metal, respiratory, food, plant/pollen and chemical allergies were not associated with risk of RA. By contrast, statistically significant associations were observed for animal dander allergy (6% vs 5%, aOR 1.37, 95% CI 1.03 to 1.82), especially in ACPA-positive RA (aOR 1.46 95% CI 1.06 to 2.01) and for atopic dermatitis, in particular for older and ACPA-negative RA (aOR 2.33, 95% CI 1.37 to 3.96 at age 80). Never smokers with allergic rhinitis also had increased risk of developing RA (aOR 1.30, 95% CI 1.00 to 1.68). CONCLUSION: Most common allergies do not increase risk of RA, nor do they protect against RA. However, some allergic conditions, notably animal dander allergy, atopic dermatitis and allergic rhinitis, were associated with an increased risk for RA. BMJ Publishing Group 2022-02-15 /pmc/articles/PMC8852704/ /pubmed/35168998 http://dx.doi.org/10.1136/rmdopen-2021-002018 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Inflammatory Arthritis
Kronzer, Vanessa L
Westerlind, Helga
Alfredsson, Lars
Crowson, Cynthia S
Klareskog, Lars
Holmqvist, Marie
Askling, Johan
Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
title Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
title_full Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
title_fullStr Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
title_full_unstemmed Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
title_short Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
title_sort allergic conditions and risk of rheumatoid arthritis: a swedish case–control study
topic Inflammatory Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852704/
https://www.ncbi.nlm.nih.gov/pubmed/35168998
http://dx.doi.org/10.1136/rmdopen-2021-002018
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