Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α

Mutations in thyroid hormone receptor α (TRα), a ligand-inducible transcription factor, cause resistance to thyroid hormone α (RTHα). This disorder is characterized by tissue-specific hormone refractoriness and hypothyroidism due to the inhibition of target gene expression by mutant TRα-corepressor...

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Detalles Bibliográficos
Autores principales: Romartinez-Alonso, Beatriz, Agostini, Maura, Jones, Heulyn, McLellan, Jayde, Sood, D. Eilidh, Tomkinson, Nicholas, Marelli, Federica, Gentile, Ilaria, Visser, W. Edward, Schoenmakers, Erik, Fairall, Louise, Privalsky, Martin, Moran, Carla, Persani, Luca, Chatterjee, Krishna, Schwabe, John W. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852717/
https://www.ncbi.nlm.nih.gov/pubmed/34871063
http://dx.doi.org/10.1128/mcb.00363-21

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