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Neutralization of Typhoid Toxin by Alpaca-Derived, Single-Domain Antibodies Targeting the PltB and CdtB Subunits

Typhoid toxin is secreted by the typhoid fever-causing bacterial pathogen Salmonella enterica serovar Typhi and has tropism for immune cells and brain endothelial cells. Here, we generated a camelid single-domain antibody (VHH) library from typhoid toxoid-immunized alpacas and identified 41 VHHs sel...

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Detalles Bibliográficos
Autores principales:	Dulal, Hari P., Vance, David J., Neupane, Durga P., Chen, Xiangcheng, Tremblay, Jacqueline M., Shoemaker, Charles B., Mantis, Nicholas J., Song, Jeongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Microbial Immunity and Vaccines
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852740/ https://www.ncbi.nlm.nih.gov/pubmed/34898253 http://dx.doi.org/10.1128/iai.00515-21

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