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Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis
The role of oral microbiota in viral encephalitis and/or viral meningitis (VEVM) remains unclear. In this hospital-based, frequency-matched study, children with clinically diagnosed VEVM (n = 68) and those with other diseases (controls, n = 68) were recruited. Their oral swab samples were collected...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Microbiological Society of Korea
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852926/ https://www.ncbi.nlm.nih.gov/pubmed/35157224 http://dx.doi.org/10.1007/s12275-022-1560-y |
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author | Li, Yijie Liu, Jing Zhu, Yimin Peng, Chunying Dong, Yao Liu, Lili He, Yining Lu, Guoping Zheng, Yingjie |
author_facet | Li, Yijie Liu, Jing Zhu, Yimin Peng, Chunying Dong, Yao Liu, Lili He, Yining Lu, Guoping Zheng, Yingjie |
author_sort | Li, Yijie |
collection | PubMed |
description | The role of oral microbiota in viral encephalitis and/or viral meningitis (VEVM) remains unclear. In this hospital-based, frequency-matched study, children with clinically diagnosed VEVM (n = 68) and those with other diseases (controls, n = 68) were recruited. Their oral swab samples were collected and the oral microbiota was profiled using 16S rRNA gene sequencing. The oral microbiota of children with VEVM exhibited different beta diversity metrics (unweighted UniFrac distance: P < 0.001, R(2) = 0.025, Bray-curtis dissimilarity: P = 0.045, R(2) = 0.011, and Jaccard dissimilarity: P < 0.001, R(2) = 0.017) and higher relative abundances of taxa identified by Linear discriminant analysis (LDA) with effect size (Enterococcus, Pedobacter, Massilia, Prevotella_9, Psychrobacter, Butyricimonas, Bradyrhizobium, etc., LDA scores > 2.0) when compared with the control group. The higher pathway abundance of steroid hormone biosynthesis predicted by oral microbiota was suggested to be linked to VEVM (q = 0.020). Further, a model based on oral microbial traits showed good predictive performance for VEVM with an area under the receiver operating characteristic curve of 0.920 (95% confidence interval: 0.834–1.000). Similar results were also obtained between children with etiologically diagnosed VEVM (n = 43) and controls (n = 68). Our preliminary study identified VEVM-specific oral microbial traits among children, which can be effective in the diagnosis of VEVM. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available in the online version of this article at 10.1007/s12275-022-1560-y. |
format | Online Article Text |
id | pubmed-8852926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Microbiological Society of Korea |
record_format | MEDLINE/PubMed |
spelling | pubmed-88529262022-02-18 Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis Li, Yijie Liu, Jing Zhu, Yimin Peng, Chunying Dong, Yao Liu, Lili He, Yining Lu, Guoping Zheng, Yingjie J Microbiol Microbial Pathogenesis and Host-Microbe Interaction The role of oral microbiota in viral encephalitis and/or viral meningitis (VEVM) remains unclear. In this hospital-based, frequency-matched study, children with clinically diagnosed VEVM (n = 68) and those with other diseases (controls, n = 68) were recruited. Their oral swab samples were collected and the oral microbiota was profiled using 16S rRNA gene sequencing. The oral microbiota of children with VEVM exhibited different beta diversity metrics (unweighted UniFrac distance: P < 0.001, R(2) = 0.025, Bray-curtis dissimilarity: P = 0.045, R(2) = 0.011, and Jaccard dissimilarity: P < 0.001, R(2) = 0.017) and higher relative abundances of taxa identified by Linear discriminant analysis (LDA) with effect size (Enterococcus, Pedobacter, Massilia, Prevotella_9, Psychrobacter, Butyricimonas, Bradyrhizobium, etc., LDA scores > 2.0) when compared with the control group. The higher pathway abundance of steroid hormone biosynthesis predicted by oral microbiota was suggested to be linked to VEVM (q = 0.020). Further, a model based on oral microbial traits showed good predictive performance for VEVM with an area under the receiver operating characteristic curve of 0.920 (95% confidence interval: 0.834–1.000). Similar results were also obtained between children with etiologically diagnosed VEVM (n = 43) and controls (n = 68). Our preliminary study identified VEVM-specific oral microbial traits among children, which can be effective in the diagnosis of VEVM. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available in the online version of this article at 10.1007/s12275-022-1560-y. The Microbiological Society of Korea 2022-02-14 2022 /pmc/articles/PMC8852926/ /pubmed/35157224 http://dx.doi.org/10.1007/s12275-022-1560-y Text en © The Microbiological Society of Korea 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Microbial Pathogenesis and Host-Microbe Interaction Li, Yijie Liu, Jing Zhu, Yimin Peng, Chunying Dong, Yao Liu, Lili He, Yining Lu, Guoping Zheng, Yingjie Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis |
title | Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis |
title_full | Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis |
title_fullStr | Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis |
title_full_unstemmed | Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis |
title_short | Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis |
title_sort | alterations of oral microbiota in chinese children with viral encephalitis and/or viral meningitis |
topic | Microbial Pathogenesis and Host-Microbe Interaction |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852926/ https://www.ncbi.nlm.nih.gov/pubmed/35157224 http://dx.doi.org/10.1007/s12275-022-1560-y |
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