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The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19

Coagulation and fibrinolytic mechanisms are enhanced in patients with coronavirus (COVID-19), but disturbances in the balance of both functions in COVID-19 patients remain unclear. We assessed global coagulation and fibrinolysis in plasma from 167 COVID-19 patients (mild/moderate/severe: 62/88/17, r...

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Autores principales: Onishi, Tomoko, Shimonishi, Naruto, Takeyama, Masahiro, Furukawa, Shoko, Ogiwara, Kenichi, Nakajima, Yuto, Kasahara, Kei, Nishio, Kenji, Yoshimoto, Kiyomi, Inoue, Satoki, Kawaguchi, Masahiko, Fukushima, Hidetada, Saito, Yoshihiko, Yoshiji, Hitoshi, Muro, Shigeo, Tsuruya, Kazuhiko, Okada, Sadanori, Sugie, Kazuma, Kawaguchi, Ryuji, Nishikubo, Toshiya, Yamazaki, Masaharu, Oda, Yukio, Kawabe, Toshiki, Onishi, Kengo, Nishio, Tomohisa, Nogami, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852977/
https://www.ncbi.nlm.nih.gov/pubmed/35171446
http://dx.doi.org/10.1007/s12185-022-03308-w
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author Onishi, Tomoko
Shimonishi, Naruto
Takeyama, Masahiro
Furukawa, Shoko
Ogiwara, Kenichi
Nakajima, Yuto
Kasahara, Kei
Nishio, Kenji
Yoshimoto, Kiyomi
Inoue, Satoki
Kawaguchi, Masahiko
Fukushima, Hidetada
Saito, Yoshihiko
Yoshiji, Hitoshi
Muro, Shigeo
Tsuruya, Kazuhiko
Okada, Sadanori
Sugie, Kazuma
Kawaguchi, Ryuji
Nishikubo, Toshiya
Yamazaki, Masaharu
Oda, Yukio
Kawabe, Toshiki
Onishi, Kengo
Nishio, Tomohisa
Nogami, Keiji
author_facet Onishi, Tomoko
Shimonishi, Naruto
Takeyama, Masahiro
Furukawa, Shoko
Ogiwara, Kenichi
Nakajima, Yuto
Kasahara, Kei
Nishio, Kenji
Yoshimoto, Kiyomi
Inoue, Satoki
Kawaguchi, Masahiko
Fukushima, Hidetada
Saito, Yoshihiko
Yoshiji, Hitoshi
Muro, Shigeo
Tsuruya, Kazuhiko
Okada, Sadanori
Sugie, Kazuma
Kawaguchi, Ryuji
Nishikubo, Toshiya
Yamazaki, Masaharu
Oda, Yukio
Kawabe, Toshiki
Onishi, Kengo
Nishio, Tomohisa
Nogami, Keiji
author_sort Onishi, Tomoko
collection PubMed
description Coagulation and fibrinolytic mechanisms are enhanced in patients with coronavirus (COVID-19), but disturbances in the balance of both functions in COVID-19 patients remain unclear. We assessed global coagulation and fibrinolysis in plasma from 167 COVID-19 patients (mild/moderate/severe: 62/88/17, respectively) on admission using clot-fibrinolysis waveform analysis (CFWA). Maximum coagulation velocity (|min1|) and maximum fibrinolysis velocity (|FL-min1|) were expressed as ratios relative to normal plasma. Ten patients (6.0%) developed thrombosis, 5 (3.0%) had bleeding tendency, and 13 (7.8%) died during admission. FDP levels increased with severity of COVID-19 symptoms (mild/moderate/severe; median 2.7/4.9/9.9 μg/mL, respectively). The |min1| ratios were elevated in all categories (1.27/1.61/1.58) in keeping with enhanced coagulation potential, with significant differences between mild cases and moderate to severe cases. The |FL-min1| ratios were also elevated in all groups (1.19/1.39/1.40), reflecting enhanced fibrinolytic potential. These data identified coagulation dominance in moderate to severe cases, but balanced coagulation and fibrinolysis in mild cases. There were significant differences in FDP and TAT, but no significant differences in |min1| or |FL-min1| ratios, between patients with and without thrombosis. CFWA monitoring of coagulation and fibrinolysis dynamics could provide valuable data for understanding hemostatic changes and disease status in COVID-19 patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12185-022-03308-w.
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spelling pubmed-88529772022-02-18 The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19 Onishi, Tomoko Shimonishi, Naruto Takeyama, Masahiro Furukawa, Shoko Ogiwara, Kenichi Nakajima, Yuto Kasahara, Kei Nishio, Kenji Yoshimoto, Kiyomi Inoue, Satoki Kawaguchi, Masahiko Fukushima, Hidetada Saito, Yoshihiko Yoshiji, Hitoshi Muro, Shigeo Tsuruya, Kazuhiko Okada, Sadanori Sugie, Kazuma Kawaguchi, Ryuji Nishikubo, Toshiya Yamazaki, Masaharu Oda, Yukio Kawabe, Toshiki Onishi, Kengo Nishio, Tomohisa Nogami, Keiji Int J Hematol Original Article Coagulation and fibrinolytic mechanisms are enhanced in patients with coronavirus (COVID-19), but disturbances in the balance of both functions in COVID-19 patients remain unclear. We assessed global coagulation and fibrinolysis in plasma from 167 COVID-19 patients (mild/moderate/severe: 62/88/17, respectively) on admission using clot-fibrinolysis waveform analysis (CFWA). Maximum coagulation velocity (|min1|) and maximum fibrinolysis velocity (|FL-min1|) were expressed as ratios relative to normal plasma. Ten patients (6.0%) developed thrombosis, 5 (3.0%) had bleeding tendency, and 13 (7.8%) died during admission. FDP levels increased with severity of COVID-19 symptoms (mild/moderate/severe; median 2.7/4.9/9.9 μg/mL, respectively). The |min1| ratios were elevated in all categories (1.27/1.61/1.58) in keeping with enhanced coagulation potential, with significant differences between mild cases and moderate to severe cases. The |FL-min1| ratios were also elevated in all groups (1.19/1.39/1.40), reflecting enhanced fibrinolytic potential. These data identified coagulation dominance in moderate to severe cases, but balanced coagulation and fibrinolysis in mild cases. There were significant differences in FDP and TAT, but no significant differences in |min1| or |FL-min1| ratios, between patients with and without thrombosis. CFWA monitoring of coagulation and fibrinolysis dynamics could provide valuable data for understanding hemostatic changes and disease status in COVID-19 patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12185-022-03308-w. Springer Nature Singapore 2022-02-16 2022 /pmc/articles/PMC8852977/ /pubmed/35171446 http://dx.doi.org/10.1007/s12185-022-03308-w Text en © Japanese Society of Hematology 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Onishi, Tomoko
Shimonishi, Naruto
Takeyama, Masahiro
Furukawa, Shoko
Ogiwara, Kenichi
Nakajima, Yuto
Kasahara, Kei
Nishio, Kenji
Yoshimoto, Kiyomi
Inoue, Satoki
Kawaguchi, Masahiko
Fukushima, Hidetada
Saito, Yoshihiko
Yoshiji, Hitoshi
Muro, Shigeo
Tsuruya, Kazuhiko
Okada, Sadanori
Sugie, Kazuma
Kawaguchi, Ryuji
Nishikubo, Toshiya
Yamazaki, Masaharu
Oda, Yukio
Kawabe, Toshiki
Onishi, Kengo
Nishio, Tomohisa
Nogami, Keiji
The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19
title The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19
title_full The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19
title_fullStr The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19
title_full_unstemmed The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19
title_short The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-19
title_sort balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe covid-19
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852977/
https://www.ncbi.nlm.nih.gov/pubmed/35171446
http://dx.doi.org/10.1007/s12185-022-03308-w
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