Circadian regulation of innate immunity in animals and humans and implications for human disease

Circadian rhythms are 24-h oscillating variations in physiology generated by the core circadian clock. There is now a wide body of evidence showing circadian regulation of the immune system. Innate immune cells contain the molecular circadian clock which drives rhythmic responses, from the magnitude...

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Detalles Bibliográficos
Autores principales: Poole, Joanna, Kitchen, Gareth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853148/
https://www.ncbi.nlm.nih.gov/pubmed/35169890
http://dx.doi.org/10.1007/s00281-022-00921-z
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author Poole, Joanna
Kitchen, Gareth B.
author_facet Poole, Joanna
Kitchen, Gareth B.
author_sort Poole, Joanna
collection PubMed
description Circadian rhythms are 24-h oscillating variations in physiology generated by the core circadian clock. There is now a wide body of evidence showing circadian regulation of the immune system. Innate immune cells contain the molecular circadian clock which drives rhythmic responses, from the magnitude of the inflammatory response to the numbers of circulating immune cells varying throughout the day. This leads to rhythmic presentation of disease clinically, for example the classic presentation of nocturnal asthma or the sudden development of pulmonary oedema from acute myocardial infarction first thing in the morning.
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spelling pubmed-88531482022-02-18 Circadian regulation of innate immunity in animals and humans and implications for human disease Poole, Joanna Kitchen, Gareth B. Semin Immunopathol Review Circadian rhythms are 24-h oscillating variations in physiology generated by the core circadian clock. There is now a wide body of evidence showing circadian regulation of the immune system. Innate immune cells contain the molecular circadian clock which drives rhythmic responses, from the magnitude of the inflammatory response to the numbers of circulating immune cells varying throughout the day. This leads to rhythmic presentation of disease clinically, for example the classic presentation of nocturnal asthma or the sudden development of pulmonary oedema from acute myocardial infarction first thing in the morning. Springer Berlin Heidelberg 2022-02-15 2022 /pmc/articles/PMC8853148/ /pubmed/35169890 http://dx.doi.org/10.1007/s00281-022-00921-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Poole, Joanna
Kitchen, Gareth B.
Circadian regulation of innate immunity in animals and humans and implications for human disease
title Circadian regulation of innate immunity in animals and humans and implications for human disease
title_full Circadian regulation of innate immunity in animals and humans and implications for human disease
title_fullStr Circadian regulation of innate immunity in animals and humans and implications for human disease
title_full_unstemmed Circadian regulation of innate immunity in animals and humans and implications for human disease
title_short Circadian regulation of innate immunity in animals and humans and implications for human disease
title_sort circadian regulation of innate immunity in animals and humans and implications for human disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853148/
https://www.ncbi.nlm.nih.gov/pubmed/35169890
http://dx.doi.org/10.1007/s00281-022-00921-z
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