MicroRNA-122-5p Aggravates Angiotensin II-Mediated Myocardial Fibrosis and Dysfunction in Hypertensive Rats by Regulating the Elabela/Apelin-APJ and ACE2-GDF15-Porimin Signaling

Hypertension is the leading risk factor for cardiovascular disorders. This study aimed to explore roles of microRNA (miR)-122-5p in hypertension. Angiotensin II (Ang II; 1.5 mg/kg/day) with an osmotic minipump was used to induce hypertensive rats pretreated by rAAV-miR-122-5p or rAAV-GFP, respective...

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Detalles Bibliográficos
Autores principales: Song, Jiawei, Zhang, Zhenzhou, Dong, Zhaojie, Liu, Xinming, Liu, Ying, Li, Xueting, Xu, Yingle, Guo, Ying, Wang, Ning, Zhang, Miwen, Chen, Yihang, Jin, Haiyan, Zhong, Jiuchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853151/
https://www.ncbi.nlm.nih.gov/pubmed/35174434
http://dx.doi.org/10.1007/s12265-022-10214-3

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