Wie sich COVID-19 in der 3D-Zellkultur simulieren lässt

Excessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe SARS-CoV-2 infection and is associated with enhanced pathogenicity and mortality. Complement hyper activation promotes lung injury and was observed in patients suffering from MERS-CoV, SARS-CoV-1 and SARS-Co...

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Detalles Bibliográficos
Autores principales: Wilflingseder, Doris, Posch, Wilfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Wissenschaft Special
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853259/
https://www.ncbi.nlm.nih.gov/pubmed/35194332
http://dx.doi.org/10.1007/s12268-022-1712-y
Descripción
Sumario:Excessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe SARS-CoV-2 infection and is associated with enhanced pathogenicity and mortality. Complement hyper activation promotes lung injury and was observed in patients suffering from MERS-CoV, SARS-CoV-1 and SARS-CoV-2 infections. To evaluate the very first interactions of SARS-CoV-2 patient isolates with human epithelial tissues, 3D models of the human respiratory tract as well as lung organoids are highly suitable.

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