Kidneys control inter-organ homeostasis

Cockayne syndrome is a genetic disease characterized by impairment of DNA repair mechanisms, premature ageing, cachexia and kidney dysfunction. New research in a mouse model of Cockayne syndrome demonstrates that injury induces a subset of kidney proximal tubule cells to express the anorexigenic pep...

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Detalles Bibliográficos
Autores principales: Puelles, Victor G., Huber, Tobias B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853303/
https://www.ncbi.nlm.nih.gov/pubmed/35165430
http://dx.doi.org/10.1038/s41581-022-00549-0
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author Puelles, Victor G.
Huber, Tobias B.
author_facet Puelles, Victor G.
Huber, Tobias B.
author_sort Puelles, Victor G.
collection PubMed
description Cockayne syndrome is a genetic disease characterized by impairment of DNA repair mechanisms, premature ageing, cachexia and kidney dysfunction. New research in a mouse model of Cockayne syndrome demonstrates that injury induces a subset of kidney proximal tubule cells to express the anorexigenic peptide GDF15. These findings link kidney injury to cachexia and highlight the role of the kidney in mediating inter-organ homeostasis.
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spelling pubmed-88533032022-02-18 Kidneys control inter-organ homeostasis Puelles, Victor G. Huber, Tobias B. Nat Rev Nephrol News & Views Cockayne syndrome is a genetic disease characterized by impairment of DNA repair mechanisms, premature ageing, cachexia and kidney dysfunction. New research in a mouse model of Cockayne syndrome demonstrates that injury induces a subset of kidney proximal tubule cells to express the anorexigenic peptide GDF15. These findings link kidney injury to cachexia and highlight the role of the kidney in mediating inter-organ homeostasis. Nature Publishing Group UK 2022-02-14 2022 /pmc/articles/PMC8853303/ /pubmed/35165430 http://dx.doi.org/10.1038/s41581-022-00549-0 Text en © Springer Nature Limited 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle News & Views
Puelles, Victor G.
Huber, Tobias B.
Kidneys control inter-organ homeostasis
title Kidneys control inter-organ homeostasis
title_full Kidneys control inter-organ homeostasis
title_fullStr Kidneys control inter-organ homeostasis
title_full_unstemmed Kidneys control inter-organ homeostasis
title_short Kidneys control inter-organ homeostasis
title_sort kidneys control inter-organ homeostasis
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853303/
https://www.ncbi.nlm.nih.gov/pubmed/35165430
http://dx.doi.org/10.1038/s41581-022-00549-0
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