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Use of Poly (Ethylene Glycol) Coated Superparamagnetic Iron Oxide Nanoparticles as Radio Sensitizer in Enhancing Colorectal Cancer Radiation Efficacy

BACKGORUND: The aim of the radiotherapy is to deliver a lethal dose to tumor while reducing the impact on the normal tissue. This reduction in impact can be achieved to have a greater therapeutic ratio by using nanoparticles as radiosensitizer. MATERIALS AND METHODS: In this article, the potential r...

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Autores principales: Anuje, Madhuri, Pawaskar, Padamaja, Sivan, Ajay, Lokhande, Chandrakant, Ahmed, Imtiaz, Patil, Dhanashree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853453/
https://www.ncbi.nlm.nih.gov/pubmed/35261497
http://dx.doi.org/10.4103/jmp.JMP_15_21
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author Anuje, Madhuri
Pawaskar, Padamaja
Sivan, Ajay
Lokhande, Chandrakant
Ahmed, Imtiaz
Patil, Dhanashree
author_facet Anuje, Madhuri
Pawaskar, Padamaja
Sivan, Ajay
Lokhande, Chandrakant
Ahmed, Imtiaz
Patil, Dhanashree
author_sort Anuje, Madhuri
collection PubMed
description BACKGORUND: The aim of the radiotherapy is to deliver a lethal dose to tumor while reducing the impact on the normal tissue. This reduction in impact can be achieved to have a greater therapeutic ratio by using nanoparticles as radiosensitizer. MATERIALS AND METHODS: In this article, the potential role of superparamagnetic iron oxide nanoparticles (SPIONs) as radiosensitization enhancer on HT 29 cell lines for different concentrations (0.007to 0.25 mg/ml) and different radiation doses (0.5to 2 Gy) of 6MV photon beam is presented. RESULTS: The highest sensitization enhancement ratio (SER) value was observed with 2 Gy for 0.25 mg/ml concentration. Radio sensitization increases with increase in the concentration of nanoparticles. Combination of 6MV energy radiation and polyethylene glycol (PEG) coated SPIONs results in increasing cell killing of HT 29 as compared to cell killing with radiation therapy alone. CONCLUSION: The results reveal that PEG coated nanoparticle might be a potential candidate to work as radiotherapy sensitizer in colorectal cancer.
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spelling pubmed-88534532022-03-07 Use of Poly (Ethylene Glycol) Coated Superparamagnetic Iron Oxide Nanoparticles as Radio Sensitizer in Enhancing Colorectal Cancer Radiation Efficacy Anuje, Madhuri Pawaskar, Padamaja Sivan, Ajay Lokhande, Chandrakant Ahmed, Imtiaz Patil, Dhanashree J Med Phys Original Article BACKGORUND: The aim of the radiotherapy is to deliver a lethal dose to tumor while reducing the impact on the normal tissue. This reduction in impact can be achieved to have a greater therapeutic ratio by using nanoparticles as radiosensitizer. MATERIALS AND METHODS: In this article, the potential role of superparamagnetic iron oxide nanoparticles (SPIONs) as radiosensitization enhancer on HT 29 cell lines for different concentrations (0.007to 0.25 mg/ml) and different radiation doses (0.5to 2 Gy) of 6MV photon beam is presented. RESULTS: The highest sensitization enhancement ratio (SER) value was observed with 2 Gy for 0.25 mg/ml concentration. Radio sensitization increases with increase in the concentration of nanoparticles. Combination of 6MV energy radiation and polyethylene glycol (PEG) coated SPIONs results in increasing cell killing of HT 29 as compared to cell killing with radiation therapy alone. CONCLUSION: The results reveal that PEG coated nanoparticle might be a potential candidate to work as radiotherapy sensitizer in colorectal cancer. Wolters Kluwer - Medknow 2021 2021-12-31 /pmc/articles/PMC8853453/ /pubmed/35261497 http://dx.doi.org/10.4103/jmp.JMP_15_21 Text en Copyright: © 2021 Journal of Medical Physics https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Anuje, Madhuri
Pawaskar, Padamaja
Sivan, Ajay
Lokhande, Chandrakant
Ahmed, Imtiaz
Patil, Dhanashree
Use of Poly (Ethylene Glycol) Coated Superparamagnetic Iron Oxide Nanoparticles as Radio Sensitizer in Enhancing Colorectal Cancer Radiation Efficacy
title Use of Poly (Ethylene Glycol) Coated Superparamagnetic Iron Oxide Nanoparticles as Radio Sensitizer in Enhancing Colorectal Cancer Radiation Efficacy
title_full Use of Poly (Ethylene Glycol) Coated Superparamagnetic Iron Oxide Nanoparticles as Radio Sensitizer in Enhancing Colorectal Cancer Radiation Efficacy
title_fullStr Use of Poly (Ethylene Glycol) Coated Superparamagnetic Iron Oxide Nanoparticles as Radio Sensitizer in Enhancing Colorectal Cancer Radiation Efficacy
title_full_unstemmed Use of Poly (Ethylene Glycol) Coated Superparamagnetic Iron Oxide Nanoparticles as Radio Sensitizer in Enhancing Colorectal Cancer Radiation Efficacy
title_short Use of Poly (Ethylene Glycol) Coated Superparamagnetic Iron Oxide Nanoparticles as Radio Sensitizer in Enhancing Colorectal Cancer Radiation Efficacy
title_sort use of poly (ethylene glycol) coated superparamagnetic iron oxide nanoparticles as radio sensitizer in enhancing colorectal cancer radiation efficacy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853453/
https://www.ncbi.nlm.nih.gov/pubmed/35261497
http://dx.doi.org/10.4103/jmp.JMP_15_21
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