Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen

Genome-wide screens that have viability as a readout have been instrumental to identify essential genes. The development of gene knockout screens with the use of CRISPR-Cas has provided a more sensitive method to identify these genes. Here, we performed an exhaustive genome-wide CRISPR/Cas9 phenotyp...

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Detalles Bibliográficos
Autores principales: Ashoti, Ator, Limone, Francesco, van Kranenburg, Melissa, Alemany, Anna, Baak, Mirna, Vivié, Judith, Piccioni, Frederica, Dijkers, Pascale F., Creyghton, Menno, Eggan, Kevin, Geijsen, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853573/
https://www.ncbi.nlm.nih.gov/pubmed/35176052
http://dx.doi.org/10.1371/journal.pone.0263262

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