Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

There is mounting evidence that microbes residing in the human intestine contribute to diverse alcohol-associated liver diseases (ALD) including the most deadly form known as alcohol-associated hepatitis (AH). However, mechanisms by which gut microbes synergize with excessive alcohol intake to promo...

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Detalles Bibliográficos
Autores principales: Helsley, Robert N, Miyata, Tatsunori, Kadam, Anagha, Varadharajan, Venkateshwari, Sangwan, Naseer, Huang, Emily C, Banerjee, Rakhee, Brown, Amanda L, Fung, Kevin K, Massey, William J, Neumann, Chase, Orabi, Danny, Osborn, Lucas J, Schugar, Rebecca C, McMullen, Megan R, Bellar, Annette, Poulsen, Kyle L, Kim, Adam, Pathak, Vai, Mrdjen, Marko, Anderson, James T, Willard, Belinda, McClain, Craig J, Mitchell, Mack, McCullough, Arthur J, Radaeva, Svetlana, Barton, Bruce, Szabo, Gyongyi, Dasarathy, Srinivasan, Garcia-Garcia, Jose Carlos, Rotroff, Daniel M, Allende, Daniela S, Wang, Zeneng, Hazen, Stanley L, Nagy, Laura E, Brown, Jonathan Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853661/
https://www.ncbi.nlm.nih.gov/pubmed/35084335
http://dx.doi.org/10.7554/eLife.76554

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