Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that bacterial microbiota stimulate a homeostatic ISG signature in the intestine of specific pathogen-free mice. This homeostatic...

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Detalles Bibliográficos
Autores principales: Van Winkle, Jacob A, Peterson, Stefan T, Kennedy, Elizabeth A, Wheadon, Michael J, Ingle, Harshad, Desai, Chandni, Rodgers, Rachel, Constant, David A, Wright, Austin P, Li, Lena, Artyomov, Maxim N, Lee, Sanghyun, Baldridge, Megan T, Nice, Timothy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853662/
https://www.ncbi.nlm.nih.gov/pubmed/35137688
http://dx.doi.org/10.7554/eLife.74072

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