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A Rare Case of Sarcoidosis Involving Male Breast Tissue

Sarcoidosis is a multisystem, inflammatory granulomatous disease that rarely involves breast tissue. The pathophysiology of this chronic granulomatous condition is not well understood but is thought to be multifactorial, involving environmental influences causing an amplified immune response. A key...

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Detalles Bibliográficos
Autores principales: Grove, John, Meier, Casey, Youssef, Bahaaeldin, Costello, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853972/
https://www.ncbi.nlm.nih.gov/pubmed/35198297
http://dx.doi.org/10.7759/cureus.21387
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author Grove, John
Meier, Casey
Youssef, Bahaaeldin
Costello, Patrick
author_facet Grove, John
Meier, Casey
Youssef, Bahaaeldin
Costello, Patrick
author_sort Grove, John
collection PubMed
description Sarcoidosis is a multisystem, inflammatory granulomatous disease that rarely involves breast tissue. The pathophysiology of this chronic granulomatous condition is not well understood but is thought to be multifactorial, involving environmental influences causing an amplified immune response. A key histomorphology feature in sarcoidosis is the presence of non-necrotizing granulomas. In this case, we report a 41-year-old African-American man with a known history of sarcoidosis of the lung who presented with gynecomastia and bilateral breast tenderness with palpable nodules. Subsequent biopsy and microscopic examination of the breast nodules revealed diffuse involvement with non-necrotizing granulomas in both breasts. A final diagnosis of extensive sarcoidosis involving breast tissue was rendered after excluding other causes of non-necrotizing granulomas. The patient underwent a bilateral mastectomy to remove the breast nodules. This case discusses sarcoidosis involving an unusual site.
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spelling pubmed-88539722022-02-22 A Rare Case of Sarcoidosis Involving Male Breast Tissue Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick Cureus Pathology Sarcoidosis is a multisystem, inflammatory granulomatous disease that rarely involves breast tissue. The pathophysiology of this chronic granulomatous condition is not well understood but is thought to be multifactorial, involving environmental influences causing an amplified immune response. A key histomorphology feature in sarcoidosis is the presence of non-necrotizing granulomas. In this case, we report a 41-year-old African-American man with a known history of sarcoidosis of the lung who presented with gynecomastia and bilateral breast tenderness with palpable nodules. Subsequent biopsy and microscopic examination of the breast nodules revealed diffuse involvement with non-necrotizing granulomas in both breasts. A final diagnosis of extensive sarcoidosis involving breast tissue was rendered after excluding other causes of non-necrotizing granulomas. The patient underwent a bilateral mastectomy to remove the breast nodules. This case discusses sarcoidosis involving an unusual site. Cureus 2022-01-18 /pmc/articles/PMC8853972/ /pubmed/35198297 http://dx.doi.org/10.7759/cureus.21387 Text en Copyright © 2022, Grove et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Grove, John
Meier, Casey
Youssef, Bahaaeldin
Costello, Patrick
A Rare Case of Sarcoidosis Involving Male Breast Tissue
title A Rare Case of Sarcoidosis Involving Male Breast Tissue
title_full A Rare Case of Sarcoidosis Involving Male Breast Tissue
title_fullStr A Rare Case of Sarcoidosis Involving Male Breast Tissue
title_full_unstemmed A Rare Case of Sarcoidosis Involving Male Breast Tissue
title_short A Rare Case of Sarcoidosis Involving Male Breast Tissue
title_sort rare case of sarcoidosis involving male breast tissue
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853972/
https://www.ncbi.nlm.nih.gov/pubmed/35198297
http://dx.doi.org/10.7759/cureus.21387
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