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A Rare Case of Sarcoidosis Involving Male Breast Tissue
Sarcoidosis is a multisystem, inflammatory granulomatous disease that rarely involves breast tissue. The pathophysiology of this chronic granulomatous condition is not well understood but is thought to be multifactorial, involving environmental influences causing an amplified immune response. A key...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853972/ https://www.ncbi.nlm.nih.gov/pubmed/35198297 http://dx.doi.org/10.7759/cureus.21387 |
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author | Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick |
author_facet | Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick |
author_sort | Grove, John |
collection | PubMed |
description | Sarcoidosis is a multisystem, inflammatory granulomatous disease that rarely involves breast tissue. The pathophysiology of this chronic granulomatous condition is not well understood but is thought to be multifactorial, involving environmental influences causing an amplified immune response. A key histomorphology feature in sarcoidosis is the presence of non-necrotizing granulomas. In this case, we report a 41-year-old African-American man with a known history of sarcoidosis of the lung who presented with gynecomastia and bilateral breast tenderness with palpable nodules. Subsequent biopsy and microscopic examination of the breast nodules revealed diffuse involvement with non-necrotizing granulomas in both breasts. A final diagnosis of extensive sarcoidosis involving breast tissue was rendered after excluding other causes of non-necrotizing granulomas. The patient underwent a bilateral mastectomy to remove the breast nodules. This case discusses sarcoidosis involving an unusual site. |
format | Online Article Text |
id | pubmed-8853972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-88539722022-02-22 A Rare Case of Sarcoidosis Involving Male Breast Tissue Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick Cureus Pathology Sarcoidosis is a multisystem, inflammatory granulomatous disease that rarely involves breast tissue. The pathophysiology of this chronic granulomatous condition is not well understood but is thought to be multifactorial, involving environmental influences causing an amplified immune response. A key histomorphology feature in sarcoidosis is the presence of non-necrotizing granulomas. In this case, we report a 41-year-old African-American man with a known history of sarcoidosis of the lung who presented with gynecomastia and bilateral breast tenderness with palpable nodules. Subsequent biopsy and microscopic examination of the breast nodules revealed diffuse involvement with non-necrotizing granulomas in both breasts. A final diagnosis of extensive sarcoidosis involving breast tissue was rendered after excluding other causes of non-necrotizing granulomas. The patient underwent a bilateral mastectomy to remove the breast nodules. This case discusses sarcoidosis involving an unusual site. Cureus 2022-01-18 /pmc/articles/PMC8853972/ /pubmed/35198297 http://dx.doi.org/10.7759/cureus.21387 Text en Copyright © 2022, Grove et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pathology Grove, John Meier, Casey Youssef, Bahaaeldin Costello, Patrick A Rare Case of Sarcoidosis Involving Male Breast Tissue |
title | A Rare Case of Sarcoidosis Involving Male Breast Tissue |
title_full | A Rare Case of Sarcoidosis Involving Male Breast Tissue |
title_fullStr | A Rare Case of Sarcoidosis Involving Male Breast Tissue |
title_full_unstemmed | A Rare Case of Sarcoidosis Involving Male Breast Tissue |
title_short | A Rare Case of Sarcoidosis Involving Male Breast Tissue |
title_sort | rare case of sarcoidosis involving male breast tissue |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853972/ https://www.ncbi.nlm.nih.gov/pubmed/35198297 http://dx.doi.org/10.7759/cureus.21387 |
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