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Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds
PURPOSE: To investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer’s disease (AD) in relation to incident dementia. METHODS: Data were derived from the population-based Gothenburg H70 Birth Cohort Studies in Sweden, including 602 dementia-free 7...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854136/ https://www.ncbi.nlm.nih.gov/pubmed/34632537 http://dx.doi.org/10.1007/s00394-021-02688-9 |
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author | Samuelsson, Jessica Najar, Jenna Wallengren, Ola Kern, Silke Wetterberg, Hanna Mellqvist Fässberg, Madeleine Zetterberg, Henrik Blennow, Kaj Lissner, Lauren Rothenberg, Elisabet Skoog, Ingmar Zettergren, Anna |
author_facet | Samuelsson, Jessica Najar, Jenna Wallengren, Ola Kern, Silke Wetterberg, Hanna Mellqvist Fässberg, Madeleine Zetterberg, Henrik Blennow, Kaj Lissner, Lauren Rothenberg, Elisabet Skoog, Ingmar Zettergren, Anna |
author_sort | Samuelsson, Jessica |
collection | PubMed |
description | PURPOSE: To investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer’s disease (AD) in relation to incident dementia. METHODS: Data were derived from the population-based Gothenburg H70 Birth Cohort Studies in Sweden, including 602 dementia-free 70-year-olds (examined 1992–93, or 2000–02; 64% women) followed for incident dementia until 2016. Two factors from a reduced rank regression analysis were translated into dietary patterns, one healthy (e.g., vegetables, fruit, and fish) and one western (e.g., red meat, refined cereals, and full-fat dairy products). Genetic risk was determined by APOE ε4 status and non-APOE AD-polygenic risk scores (AD-PRSs). Gene–diet interactions in relation to incident dementia were analysed with Cox regression models. The interaction p value threshold was < 0.1. RESULTS: There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs. Those with higher adherence to a healthy dietary pattern had a reduced risk of dementia among ε4 non-carriers (HR: 0.77; 95% CI: 0.61; 0.98), but not among ε4 carriers (HR: 0.86; CI: 0.63; 1.18). Those with a higher adherence to the western dietary pattern had an increased risk of dementia among ε4 carriers (HR: 1.37; 95% CI: 1.05; 1.78), while no association was observed among ε4 non-carriers (HR: 0.99; CI: 0.81; 1.21). CONCLUSIONS: The results of this study suggest that there is an interplay between dietary patterns and APOE ε4 status in relation to incident dementia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-021-02688-9. |
format | Online Article Text |
id | pubmed-8854136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-88541362022-02-23 Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds Samuelsson, Jessica Najar, Jenna Wallengren, Ola Kern, Silke Wetterberg, Hanna Mellqvist Fässberg, Madeleine Zetterberg, Henrik Blennow, Kaj Lissner, Lauren Rothenberg, Elisabet Skoog, Ingmar Zettergren, Anna Eur J Nutr Original Contribution PURPOSE: To investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer’s disease (AD) in relation to incident dementia. METHODS: Data were derived from the population-based Gothenburg H70 Birth Cohort Studies in Sweden, including 602 dementia-free 70-year-olds (examined 1992–93, or 2000–02; 64% women) followed for incident dementia until 2016. Two factors from a reduced rank regression analysis were translated into dietary patterns, one healthy (e.g., vegetables, fruit, and fish) and one western (e.g., red meat, refined cereals, and full-fat dairy products). Genetic risk was determined by APOE ε4 status and non-APOE AD-polygenic risk scores (AD-PRSs). Gene–diet interactions in relation to incident dementia were analysed with Cox regression models. The interaction p value threshold was < 0.1. RESULTS: There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs. Those with higher adherence to a healthy dietary pattern had a reduced risk of dementia among ε4 non-carriers (HR: 0.77; 95% CI: 0.61; 0.98), but not among ε4 carriers (HR: 0.86; CI: 0.63; 1.18). Those with a higher adherence to the western dietary pattern had an increased risk of dementia among ε4 carriers (HR: 1.37; 95% CI: 1.05; 1.78), while no association was observed among ε4 non-carriers (HR: 0.99; CI: 0.81; 1.21). CONCLUSIONS: The results of this study suggest that there is an interplay between dietary patterns and APOE ε4 status in relation to incident dementia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-021-02688-9. Springer Berlin Heidelberg 2021-10-10 2022 /pmc/articles/PMC8854136/ /pubmed/34632537 http://dx.doi.org/10.1007/s00394-021-02688-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Contribution Samuelsson, Jessica Najar, Jenna Wallengren, Ola Kern, Silke Wetterberg, Hanna Mellqvist Fässberg, Madeleine Zetterberg, Henrik Blennow, Kaj Lissner, Lauren Rothenberg, Elisabet Skoog, Ingmar Zettergren, Anna Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds |
title | Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds |
title_full | Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds |
title_fullStr | Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds |
title_full_unstemmed | Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds |
title_short | Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds |
title_sort | interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds |
topic | Original Contribution |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854136/ https://www.ncbi.nlm.nih.gov/pubmed/34632537 http://dx.doi.org/10.1007/s00394-021-02688-9 |
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