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Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes

OBJECTIVES: The applicability of proton-transfer-reaction mass spectrometry (PTR-MS) as a versatile online monitoring tool to increase consistency and robustness for recombinant adeno-associated virus (rAAV) producing HEK 293 bioprocesses was evaluated. We present a structured workflow to extract pr...

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Detalles Bibliográficos
Autores principales:	Bayer, Benjamin, Maccani, Andreas, Jahn, Johanna, Duerkop, Mark, Kapeller, Ewald, Pletzenauer, Robert, Kraus, Barbara, Striedner, Gerald, Hernandez Bort, Juan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2021
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854141/ https://www.ncbi.nlm.nih.gov/pubmed/34767126 http://dx.doi.org/10.1007/s10529-021-03205-y

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