A secondary role for hypoxia and HIF1 in the regulation of (IFNγ-induced) PD-L1 expression in melanoma

Cancer cells are able to escape immune surveillance by upregulating programmed death ligand 1 (PD-L1). A key regulator of PD-L1 expression is transcriptional stimulation by the IFNγ/JAK/STAT pathway. Recent studies suggest that hypoxia can induce PD-L1 expression. As hypoxia presents a hallmark of s...

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Detalles Bibliográficos
Autores principales: van Duijn, Anneloes, Willemsen, Karin J., van Uden, Nathalie O. P., Hoyng, Lieke, Erades, Sterre, Koster, Jan, Luiten, Rosalie M., Bakker, Walbert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854324/
https://www.ncbi.nlm.nih.gov/pubmed/34268602
http://dx.doi.org/10.1007/s00262-021-03007-1

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