Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus

Neuropsychiatric lupus (NPSLE) is a frequent manifestation of systemic lupus erythematosus (SLE) that occurs in 40–90% of SLE patients; however, the underlying mechanisms remain elusive, causing a severe lack of therapeutic targets for this condition. Here, we show that complement-coordinated elimin...

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Detalles Bibliográficos
Autores principales: Han, Xiaojuan, Xu, Tianshu, Ding, Congzhu, Wang, Dandan, Yao, Genhong, Chen, Hongwei, Fang, Qijun, Hu, Gang, Sun, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854434/
https://www.ncbi.nlm.nih.gov/pubmed/35177587
http://dx.doi.org/10.1038/s41392-021-00867-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854434/
https://www.ncbi.nlm.nih.gov/pubmed/35177587
http://dx.doi.org/10.1038/s41392-021-00867-y

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