Cargando…
Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period
Studies on the acceptance of prenatal diagnosis and termination of pregnancy for single gene disorders within Islamic societies in the Middle East are limited. A few have examined the attitudes toward pregnancy termination for fetal indications, but a dearth of published data exists on actual behavi...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854480/ https://www.ncbi.nlm.nih.gov/pubmed/35179721 http://dx.doi.org/10.1007/s12687-022-00584-1 |
_version_ | 1784653447732133888 |
---|---|
author | Bruwer, Zandré Al Ubaidani, Salwa Al Kharusi, Khalsa Al Murshedi, Fathiya Al-Maawali, Almundher Al Sayegh, Abeer Al Kindy, Adila Al Riyami, Nihal Al Dughaishi, Tamima Al Salmani, Mouza Al Hashmi, Nadia Al Shehhi, Maryam Al Fahdi, Badriya Al Amri, Sumaya Al-Thihli, Khalid |
author_facet | Bruwer, Zandré Al Ubaidani, Salwa Al Kharusi, Khalsa Al Murshedi, Fathiya Al-Maawali, Almundher Al Sayegh, Abeer Al Kindy, Adila Al Riyami, Nihal Al Dughaishi, Tamima Al Salmani, Mouza Al Hashmi, Nadia Al Shehhi, Maryam Al Fahdi, Badriya Al Amri, Sumaya Al-Thihli, Khalid |
author_sort | Bruwer, Zandré |
collection | PubMed |
description | Studies on the acceptance of prenatal diagnosis and termination of pregnancy for single gene disorders within Islamic societies in the Middle East are limited. A few have examined the attitudes toward pregnancy termination for fetal indications, but a dearth of published data exists on actual behavior and uptake. This study reports on all prenatal diagnosis requests for single gene disorders, from the Sultanate of Oman, over 9 years. A retrospective study was conducted during which the medical records of all women who performed prenatal diagnoses for single gene disorders were reviewed. A total of 148 invasive procedures were performed for 114 families. The total number of yearly requests for prenatal diagnosis increased exponentially from three in 2012 to 21 in 2020. Sixty-four different diagnoses were tested for with the majority being autosomal recessive in nature. Seventy-one percent (28/39) of cases where an affected pregnancy was identified were terminated. Fifty-two of the 114 women (45.6%) repeated prenatal diagnosis in a future pregnancy. Seventy-two couples (63%) were consanguineous parents related as second cousins or closer. The majority of tests performed were for couples from Muscat (27%), Albatinah (27%), and Alsharqiya (20.3%) governorates in Oman. The findings of this study provide evidence that prenatal diagnosis is an acceptable reproductive option to prevent the occurrence of genetic disorders that meet termination eligibility criteria as outlined by the Islamic Jurisprudence (Fiqh) Council Fatwa, among Omani Muslim couples. |
format | Online Article Text |
id | pubmed-8854480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-88544802022-02-18 Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period Bruwer, Zandré Al Ubaidani, Salwa Al Kharusi, Khalsa Al Murshedi, Fathiya Al-Maawali, Almundher Al Sayegh, Abeer Al Kindy, Adila Al Riyami, Nihal Al Dughaishi, Tamima Al Salmani, Mouza Al Hashmi, Nadia Al Shehhi, Maryam Al Fahdi, Badriya Al Amri, Sumaya Al-Thihli, Khalid J Community Genet Original Article Studies on the acceptance of prenatal diagnosis and termination of pregnancy for single gene disorders within Islamic societies in the Middle East are limited. A few have examined the attitudes toward pregnancy termination for fetal indications, but a dearth of published data exists on actual behavior and uptake. This study reports on all prenatal diagnosis requests for single gene disorders, from the Sultanate of Oman, over 9 years. A retrospective study was conducted during which the medical records of all women who performed prenatal diagnoses for single gene disorders were reviewed. A total of 148 invasive procedures were performed for 114 families. The total number of yearly requests for prenatal diagnosis increased exponentially from three in 2012 to 21 in 2020. Sixty-four different diagnoses were tested for with the majority being autosomal recessive in nature. Seventy-one percent (28/39) of cases where an affected pregnancy was identified were terminated. Fifty-two of the 114 women (45.6%) repeated prenatal diagnosis in a future pregnancy. Seventy-two couples (63%) were consanguineous parents related as second cousins or closer. The majority of tests performed were for couples from Muscat (27%), Albatinah (27%), and Alsharqiya (20.3%) governorates in Oman. The findings of this study provide evidence that prenatal diagnosis is an acceptable reproductive option to prevent the occurrence of genetic disorders that meet termination eligibility criteria as outlined by the Islamic Jurisprudence (Fiqh) Council Fatwa, among Omani Muslim couples. Springer Berlin Heidelberg 2022-02-18 2022-06 /pmc/articles/PMC8854480/ /pubmed/35179721 http://dx.doi.org/10.1007/s12687-022-00584-1 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
spellingShingle | Original Article Bruwer, Zandré Al Ubaidani, Salwa Al Kharusi, Khalsa Al Murshedi, Fathiya Al-Maawali, Almundher Al Sayegh, Abeer Al Kindy, Adila Al Riyami, Nihal Al Dughaishi, Tamima Al Salmani, Mouza Al Hashmi, Nadia Al Shehhi, Maryam Al Fahdi, Badriya Al Amri, Sumaya Al-Thihli, Khalid Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period |
title | Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period |
title_full | Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period |
title_fullStr | Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period |
title_full_unstemmed | Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period |
title_short | Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period |
title_sort | uptake of prenatal genetic diagnosis and termination of pregnancy by omani muslim families at risk of genetic disorders: experience over a 9-year period |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854480/ https://www.ncbi.nlm.nih.gov/pubmed/35179721 http://dx.doi.org/10.1007/s12687-022-00584-1 |
work_keys_str_mv | AT bruwerzandre uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alubaidanisalwa uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alkharusikhalsa uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT almurshedifathiya uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT almaawalialmundher uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alsayeghabeer uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alkindyadila uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alriyaminihal uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT aldughaishitamima uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alsalmanimouza uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alhashminadia uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alshehhimaryam uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alfahdibadriya uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT alamrisumaya uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod AT althihlikhalid uptakeofprenatalgeneticdiagnosisandterminationofpregnancybyomanimuslimfamiliesatriskofgeneticdisordersexperienceovera9yearperiod |