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The Real-Time and Patient-Specific Prediction for Duration and Recovery Profile of Cisatracurium Based on Deep Learning Models
During general anesthesia, how to judge the patient’s muscle relaxation state has always been one of the most significant issues for anesthesiologists. Train-of-four ratio (TOFR) monitoring is a standard method, which can only obtain static data to judge the current situation of muscle relaxation. C...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854501/ https://www.ncbi.nlm.nih.gov/pubmed/35185552 http://dx.doi.org/10.3389/fphar.2021.831149 |
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author | Wang, Kan Gao, Binyu Liu, Heqi Chen, Hui Liu, Honglei |
author_facet | Wang, Kan Gao, Binyu Liu, Heqi Chen, Hui Liu, Honglei |
author_sort | Wang, Kan |
collection | PubMed |
description | During general anesthesia, how to judge the patient’s muscle relaxation state has always been one of the most significant issues for anesthesiologists. Train-of-four ratio (TOFR) monitoring is a standard method, which can only obtain static data to judge the current situation of muscle relaxation. Cisatracurium is a nondepolarizing benzylisoquinoline muscle relaxant. Real-time prediction of TOFR could help anesthesiologists to evaluate the duration and recovery profile of cisatracurium. TOFR of cisatracurium could be regarded as temporal sequence data, which could be processed and predicted using RNN based deep learning methods. In this work, we performed RNN, GRU, and LSTM models for TOFR prediction. We used transfer learning based on patient similarity derived from BMI and age to achieve real-time and patient-specific prediction. The GRU model achieved the best performance. In transfer learning, the model chosen based on patient similarity has significantly outperformed the model chosen randomly. Our work verified the feasibility of real-time prediction for TOFR of cisatracurium, which had practical significance in general anesthesia. Meanwhile, using the patient demographic data in transfer learning, our work could also achieve the patient-specific prediction, having theoretical value for the clinical research of precision medicine. |
format | Online Article Text |
id | pubmed-8854501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88545012022-02-19 The Real-Time and Patient-Specific Prediction for Duration and Recovery Profile of Cisatracurium Based on Deep Learning Models Wang, Kan Gao, Binyu Liu, Heqi Chen, Hui Liu, Honglei Front Pharmacol Pharmacology During general anesthesia, how to judge the patient’s muscle relaxation state has always been one of the most significant issues for anesthesiologists. Train-of-four ratio (TOFR) monitoring is a standard method, which can only obtain static data to judge the current situation of muscle relaxation. Cisatracurium is a nondepolarizing benzylisoquinoline muscle relaxant. Real-time prediction of TOFR could help anesthesiologists to evaluate the duration and recovery profile of cisatracurium. TOFR of cisatracurium could be regarded as temporal sequence data, which could be processed and predicted using RNN based deep learning methods. In this work, we performed RNN, GRU, and LSTM models for TOFR prediction. We used transfer learning based on patient similarity derived from BMI and age to achieve real-time and patient-specific prediction. The GRU model achieved the best performance. In transfer learning, the model chosen based on patient similarity has significantly outperformed the model chosen randomly. Our work verified the feasibility of real-time prediction for TOFR of cisatracurium, which had practical significance in general anesthesia. Meanwhile, using the patient demographic data in transfer learning, our work could also achieve the patient-specific prediction, having theoretical value for the clinical research of precision medicine. Frontiers Media S.A. 2022-02-04 /pmc/articles/PMC8854501/ /pubmed/35185552 http://dx.doi.org/10.3389/fphar.2021.831149 Text en Copyright © 2022 Wang, Gao, Liu, Chen and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Wang, Kan Gao, Binyu Liu, Heqi Chen, Hui Liu, Honglei The Real-Time and Patient-Specific Prediction for Duration and Recovery Profile of Cisatracurium Based on Deep Learning Models |
title | The Real-Time and Patient-Specific Prediction for Duration and Recovery Profile of Cisatracurium Based on Deep Learning Models |
title_full | The Real-Time and Patient-Specific Prediction for Duration and Recovery Profile of Cisatracurium Based on Deep Learning Models |
title_fullStr | The Real-Time and Patient-Specific Prediction for Duration and Recovery Profile of Cisatracurium Based on Deep Learning Models |
title_full_unstemmed | The Real-Time and Patient-Specific Prediction for Duration and Recovery Profile of Cisatracurium Based on Deep Learning Models |
title_short | The Real-Time and Patient-Specific Prediction for Duration and Recovery Profile of Cisatracurium Based on Deep Learning Models |
title_sort | real-time and patient-specific prediction for duration and recovery profile of cisatracurium based on deep learning models |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854501/ https://www.ncbi.nlm.nih.gov/pubmed/35185552 http://dx.doi.org/10.3389/fphar.2021.831149 |
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