Elevated Detection of Dual Antibody B Cells Identifies Lupus Patients With B Cell-Reactive VH4-34 Autoantibodies

About 5% of B cells in healthy mice and humans are allelically or isotypically included and hence co-express two different antibodies. In mice, dual antibody B cells (B(2R)) expand with systemic autoimmunity, co-express autoreactive and non-autoreactive antibodies, and participate in immune response...

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Detalles Bibliográficos
Autores principales: Peterson, Jacob N., Boackle, Susan A., Taitano, Sophina H., Sang, Allison, Lang, Julie, Kelly, Margot, Rahkola, Jeremy T., Miranda, Anjelica M., Sheridan, Ryan M., Thurman, Joshua M., Rao, V. Koneti, Torres, Raul M., Pelanda, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854503/
https://www.ncbi.nlm.nih.gov/pubmed/35185888
http://dx.doi.org/10.3389/fimmu.2022.795209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854503/
https://www.ncbi.nlm.nih.gov/pubmed/35185888
http://dx.doi.org/10.3389/fimmu.2022.795209

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