TRPC3 shapes the ER-mitochondria Ca(2+) transfer characterizing tumour-promoting senescence

Cellular senescence is implicated in a great number of diseases including cancer. Although alterations in mitochondrial metabolism were reported as senescence drivers, the underlying mechanisms remain elusive. We report the mechanism altering mitochondrial function and OXPHOS in stress-induced senes...

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Detalles Bibliográficos
Autores principales: Farfariello, Valerio, Gordienko, Dmitri V., Mesilmany, Lina, Touil, Yasmine, Germain, Emmanuelle, Fliniaux, Ingrid, Desruelles, Emilie, Gkika, Dimitra, Roudbaraki, Morad, Shapovalov, George, Noyer, Lucile, Lebas, Mathilde, Allart, Laurent, Zienthal-Gelus, Nathalie, Iamshanova, Oksana, Bonardi, Franck, Figeac, Martin, Laine, William, Kluza, Jerome, Marchetti, Philippe, Quesnel, Bruno, Metzger, Daniel, Bernard, David, Parys, Jan B., Lemonnier, Loïc, Prevarskaya, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854551/
https://www.ncbi.nlm.nih.gov/pubmed/35177596
http://dx.doi.org/10.1038/s41467-022-28597-x

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