Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss

In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and high-throughput analyses, we demonstrate that prolonged HIF-1α si...

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Detalles Bibliográficos
Autores principales: Meng, Xianyi, Lin, Zhen, Cao, Shan, Janowska, Iga, Sonomoto, Koshiro, Andreev, Darja, Katharina, Knab, Wen, Jinming, Knaup, Karl Xaver, Wiesener, Michael Sean, Krönke, Gerhard, Rizzi, Marta, Schett, Georg, Bozec, Aline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854586/
https://www.ncbi.nlm.nih.gov/pubmed/35177582
http://dx.doi.org/10.1038/s41413-022-00189-x

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