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ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety

Allergic asthma is a chronic inflammatory respiratory disease. Psychiatric disorders, including anxiety are associated with poorer treatment response and disease control in asthmatic patients. To date, there is no experimental evidence describing the role of peripheral inflammation on the oscillator...

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Autores principales: Gholami-Mahtaj, Leila, Mooziri, Morteza, Dehdar, Kolsoum, Abdolsamadi, Maryam, Salimi, Morteza, Raoufy, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854589/
https://www.ncbi.nlm.nih.gov/pubmed/35177766
http://dx.doi.org/10.1038/s41598-022-06748-w
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author Gholami-Mahtaj, Leila
Mooziri, Morteza
Dehdar, Kolsoum
Abdolsamadi, Maryam
Salimi, Morteza
Raoufy, Mohammad Reza
author_facet Gholami-Mahtaj, Leila
Mooziri, Morteza
Dehdar, Kolsoum
Abdolsamadi, Maryam
Salimi, Morteza
Raoufy, Mohammad Reza
author_sort Gholami-Mahtaj, Leila
collection PubMed
description Allergic asthma is a chronic inflammatory respiratory disease. Psychiatric disorders, including anxiety are associated with poorer treatment response and disease control in asthmatic patients. To date, there is no experimental evidence describing the role of peripheral inflammation on the oscillatory activities in the anterior cingulate cortex (ACC) and basolateral amygdala (BLA), two major brain structures modulating anxiety. In the present work we evaluated lung and brain inflammatory responses, anxiety-like behavior, in association with oscillatory features of the ACC-BLA circuit in an animal model of allergic inflammation. Our data showed that allergic inflammation induced anxiety-like behavior and reactivation of microglia and astrocytes in ACC and BLA. Allergic inflammation also enhanced neuronal activities and functional connectivity of the ACC-BLA circuit which were correlated with the level of anxiety. Together, we suggest that disruption in the dynamic oscillatory activities of the ACC-BLA circuit, maybe due to regional inflammation, is an underlying mechanism of allergic asthma-induced anxiety-like behavior. Our findings could pave the way for better understanding the neuro-pathophysiology of the psychiatric disorders observed in asthmatic patients, possibly leading to develop novel treatment strategies.
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spelling pubmed-88545892022-02-18 ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety Gholami-Mahtaj, Leila Mooziri, Morteza Dehdar, Kolsoum Abdolsamadi, Maryam Salimi, Morteza Raoufy, Mohammad Reza Sci Rep Article Allergic asthma is a chronic inflammatory respiratory disease. Psychiatric disorders, including anxiety are associated with poorer treatment response and disease control in asthmatic patients. To date, there is no experimental evidence describing the role of peripheral inflammation on the oscillatory activities in the anterior cingulate cortex (ACC) and basolateral amygdala (BLA), two major brain structures modulating anxiety. In the present work we evaluated lung and brain inflammatory responses, anxiety-like behavior, in association with oscillatory features of the ACC-BLA circuit in an animal model of allergic inflammation. Our data showed that allergic inflammation induced anxiety-like behavior and reactivation of microglia and astrocytes in ACC and BLA. Allergic inflammation also enhanced neuronal activities and functional connectivity of the ACC-BLA circuit which were correlated with the level of anxiety. Together, we suggest that disruption in the dynamic oscillatory activities of the ACC-BLA circuit, maybe due to regional inflammation, is an underlying mechanism of allergic asthma-induced anxiety-like behavior. Our findings could pave the way for better understanding the neuro-pathophysiology of the psychiatric disorders observed in asthmatic patients, possibly leading to develop novel treatment strategies. Nature Publishing Group UK 2022-02-17 /pmc/articles/PMC8854589/ /pubmed/35177766 http://dx.doi.org/10.1038/s41598-022-06748-w Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gholami-Mahtaj, Leila
Mooziri, Morteza
Dehdar, Kolsoum
Abdolsamadi, Maryam
Salimi, Morteza
Raoufy, Mohammad Reza
ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety
title ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety
title_full ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety
title_fullStr ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety
title_full_unstemmed ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety
title_short ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety
title_sort acc-bla functional connectivity disruption in allergic inflammation is associated with anxiety
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854589/
https://www.ncbi.nlm.nih.gov/pubmed/35177766
http://dx.doi.org/10.1038/s41598-022-06748-w
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