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A One-Armed Phase I Dose Escalation Trial Design: Personalized Vaccination with IKKβ-Matured, RNA-Loaded Dendritic Cells for Metastatic Uveal Melanoma

Uveal melanoma (UM) is an orphan disease with a mortality of 80% within one year upon the development of metastatic disease. UM does hardly respond to chemotherapy and kinase inhibitors and is largely resistant to checkpoint inhibition. Hence, further therapy approaches are urgently needed. To impro...

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Detalles Bibliográficos
Autores principales:	Koch, Elias A. T., Schaft, Niels, Kummer, Mirko, Berking, Carola, Schuler, Gerold, Hasumi, Kenichiro, Dörrie, Jan, Schuler-Thurner, Beatrice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854646/ https://www.ncbi.nlm.nih.gov/pubmed/35185883 http://dx.doi.org/10.3389/fimmu.2022.785231

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