ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1

Human T-cell leukemia virus 1 (HTLV-1) causes adult T-cell leukemia (ATL), but the mechanism underlying its initiation remains elusive. In this study, ORP4L was expressed in ATL cells but not in normal T-cells. ORP4L ablation completely blocked T-cell leukemogenesis induced by the HTLV-1 oncoprotein...

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Detalles Bibliográficos
Autores principales: Zhong, Wenbin, Cao, Xiuye, Pan, Guoping, Niu, Qun, Feng, Xiaoqin, Xu, Mengyang, Li, Mingchuan, Huang, Yu, Yi, Qing, Yan, Daoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854678/
https://www.ncbi.nlm.nih.gov/pubmed/34797912
http://dx.doi.org/10.1182/blood.2021013579

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