ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis

During development, pseudostratified epithelia undergo large scale morphogenetic events associated with increased mechanical stress. Using a variety of genetic and imaging approaches, we uncover that in the mouse E6.5 epiblast, where apical tension is highest, ASPP2 safeguards tissue integrity. It a...

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Detalles Bibliográficos
Autores principales: Royer, Christophe, Sandham, Elizabeth, Slee, Elizabeth, Schneider, Falk, Lagerholm, Christoffer B., Godwin, Jonathan, Veits, Nisha, Hathrell, Holly, Zhou, Felix, Leonavicius, Karolis, Garratt, Jemma, Narendra, Tanaya, Vincent, Anna, Jones, Celine, Child, Tim, Coward, Kevin, Graham, Chris, Fritzsche, Marco, Lu, Xin, Srinivas, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854694/
https://www.ncbi.nlm.nih.gov/pubmed/35177595
http://dx.doi.org/10.1038/s41467-022-28590-4

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