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Partial Monosomy 21 Mirrors Gene Expression of Trisomy 21 in a Patient-Derived Neuroepithelial Stem Cell Model

Induced pluripotent stem cells (iPSCs) from patients are an attractive disease model to study tissues with poor accessibility such as the brain. Using this approach, we and others have shown that trisomy 21 results in genome-wide transcriptional dysregulations. The effects of loss of genes on chromo...

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Detalles Bibliográficos
Autores principales:	Schuy, Jakob, Eisfeldt, Jesper, Pettersson, Maria, Shahrokhshahi, Niloofar, Moslem, Mohsen, Nilsson, Daniel, Dahl, Niklas, Shahsavani, Mansoureh, Falk, Anna, Lindstrand, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854775/ https://www.ncbi.nlm.nih.gov/pubmed/35186010 http://dx.doi.org/10.3389/fgene.2021.803683

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