Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors

Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-specific deletion of IR or IGF1R individually results i...

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Detalles Bibliográficos
Autores principales: Bhardwaj, Gourav, Penniman, Christie M., Klaus, Katherine, Weatherford, Eric T., Pan, Hui, Dreyfuss, Jonathan M., Nair, K. Sreekumaran, Kahn, C. Ronald, O’Neill, Brian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855073/
https://www.ncbi.nlm.nih.gov/pubmed/35185597
http://dx.doi.org/10.3389/fphys.2021.779121

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