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Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases
Oral diseases impose a major health burden worldwide and have a profound effect on general health. Dental caries, periodontal diseases, and oral cancers are the most common oral health conditions. Their occurrence and development are related to oral microbes, and effective measures for their prevent...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855094/ https://www.ncbi.nlm.nih.gov/pubmed/35186787 http://dx.doi.org/10.3389/fcimb.2022.775236 |
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author | Zhang, Yuwei Ren, Liang Wang, Qi Wen, Zhining Liu, Chengcheng Ding, Yi |
author_facet | Zhang, Yuwei Ren, Liang Wang, Qi Wen, Zhining Liu, Chengcheng Ding, Yi |
author_sort | Zhang, Yuwei |
collection | PubMed |
description | Oral diseases impose a major health burden worldwide and have a profound effect on general health. Dental caries, periodontal diseases, and oral cancers are the most common oral health conditions. Their occurrence and development are related to oral microbes, and effective measures for their prevention and the promotion of oral health are urgently needed. Raman spectroscopy detects molecular vibration information by collecting inelastic scattering light, allowing a “fingerprint” of a sample to be acquired. It provides the advantages of rapid, sensitive, accurate, and minimally invasive detection as well as minimal interference from water in the “fingerprint region.” Owing to these characteristics, Raman spectroscopy has been used in medical detection in various fields to assist diagnosis and evaluate prognosis, such as detecting and differentiating between bacteria or between neoplastic and normal brain tissues. Many oral diseases are related to oral microbial dysbiosis, and their lesions differ from normal tissues in essential components. The colonization of keystone pathogens, such as Porphyromonas gingivalis, resulting in microbial dysbiosis in subgingival plaque, is the main cause of periodontitis. Moreover, the components in gingival crevicular fluid, such as infiltrating inflammatory cells and tissue degradation products, are markedly different between individuals with and without periodontitis. Regarding dental caries, the compositions of decayed teeth are transformed, accompanied by an increase in acid-producing bacteria. In oral cancers, the compositions and structures of lesions and normal tissues are different. Thus, the changes in bacteria and the components of saliva and tissue can be used in examinations as special markers for these oral diseases, and Raman spectroscopy has been acknowledged as a promising measure for detecting these markers. This review summarizes and discusses key research and remaining problems in this area. Based on this, suggestions for further study are proposed. |
format | Online Article Text |
id | pubmed-8855094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88550942022-02-19 Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases Zhang, Yuwei Ren, Liang Wang, Qi Wen, Zhining Liu, Chengcheng Ding, Yi Front Cell Infect Microbiol Cellular and Infection Microbiology Oral diseases impose a major health burden worldwide and have a profound effect on general health. Dental caries, periodontal diseases, and oral cancers are the most common oral health conditions. Their occurrence and development are related to oral microbes, and effective measures for their prevention and the promotion of oral health are urgently needed. Raman spectroscopy detects molecular vibration information by collecting inelastic scattering light, allowing a “fingerprint” of a sample to be acquired. It provides the advantages of rapid, sensitive, accurate, and minimally invasive detection as well as minimal interference from water in the “fingerprint region.” Owing to these characteristics, Raman spectroscopy has been used in medical detection in various fields to assist diagnosis and evaluate prognosis, such as detecting and differentiating between bacteria or between neoplastic and normal brain tissues. Many oral diseases are related to oral microbial dysbiosis, and their lesions differ from normal tissues in essential components. The colonization of keystone pathogens, such as Porphyromonas gingivalis, resulting in microbial dysbiosis in subgingival plaque, is the main cause of periodontitis. Moreover, the components in gingival crevicular fluid, such as infiltrating inflammatory cells and tissue degradation products, are markedly different between individuals with and without periodontitis. Regarding dental caries, the compositions of decayed teeth are transformed, accompanied by an increase in acid-producing bacteria. In oral cancers, the compositions and structures of lesions and normal tissues are different. Thus, the changes in bacteria and the components of saliva and tissue can be used in examinations as special markers for these oral diseases, and Raman spectroscopy has been acknowledged as a promising measure for detecting these markers. This review summarizes and discusses key research and remaining problems in this area. Based on this, suggestions for further study are proposed. Frontiers Media S.A. 2022-02-04 /pmc/articles/PMC8855094/ /pubmed/35186787 http://dx.doi.org/10.3389/fcimb.2022.775236 Text en Copyright © 2022 Zhang, Ren, Wang, Wen, Liu and Ding https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Zhang, Yuwei Ren, Liang Wang, Qi Wen, Zhining Liu, Chengcheng Ding, Yi Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases |
title | Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases |
title_full | Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases |
title_fullStr | Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases |
title_full_unstemmed | Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases |
title_short | Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases |
title_sort | raman spectroscopy: a potential diagnostic tool for oral diseases |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855094/ https://www.ncbi.nlm.nih.gov/pubmed/35186787 http://dx.doi.org/10.3389/fcimb.2022.775236 |
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