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Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity

Pleiotropy assessment is critical for the validity of Mendelian randomization (MR) analyses, and its management remains a challenging task for researchers. This review examines how the authors of MR studies address bias due to pleiotropy in practice. We reviewed Pubmed, Medline, Embase and Web of Sc...

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Detalles Bibliográficos
Autores principales:	Mbutiwi, Fiston Ikwa Ndol, Dessy, Tatiana, Sylvestre, Marie-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855149/ https://www.ncbi.nlm.nih.gov/pubmed/35186031 http://dx.doi.org/10.3389/fgene.2022.803238

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