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Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass

[Image: see text] Analyzing the δ(2)H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at le...

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Detalles Bibliográficos
Autores principales: Gharibi, Hassan, Chernobrovkin, Alexey L., Eriksson, Gunilla, Saei, Amir Ata, Timmons, Zena, Kitchener, Andrew C., Kalthoff, Daniela C., Lidén, Kerstin, Makarov, Alexander A., Zubarev, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855419/
https://www.ncbi.nlm.nih.gov/pubmed/35107291
http://dx.doi.org/10.1021/jacs.1c12512
Descripción
Sumario:[Image: see text] Analyzing the δ(2)H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher δ(2)H than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that “you are what you eat”.