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Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass

[Image: see text] Analyzing the δ(2)H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at le...

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Autores principales: Gharibi, Hassan, Chernobrovkin, Alexey L., Eriksson, Gunilla, Saei, Amir Ata, Timmons, Zena, Kitchener, Andrew C., Kalthoff, Daniela C., Lidén, Kerstin, Makarov, Alexander A., Zubarev, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855419/
https://www.ncbi.nlm.nih.gov/pubmed/35107291
http://dx.doi.org/10.1021/jacs.1c12512
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author Gharibi, Hassan
Chernobrovkin, Alexey L.
Eriksson, Gunilla
Saei, Amir Ata
Timmons, Zena
Kitchener, Andrew C.
Kalthoff, Daniela C.
Lidén, Kerstin
Makarov, Alexander A.
Zubarev, Roman A.
author_facet Gharibi, Hassan
Chernobrovkin, Alexey L.
Eriksson, Gunilla
Saei, Amir Ata
Timmons, Zena
Kitchener, Andrew C.
Kalthoff, Daniela C.
Lidén, Kerstin
Makarov, Alexander A.
Zubarev, Roman A.
author_sort Gharibi, Hassan
collection PubMed
description [Image: see text] Analyzing the δ(2)H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher δ(2)H than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that “you are what you eat”.
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spelling pubmed-88554192022-02-22 Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass Gharibi, Hassan Chernobrovkin, Alexey L. Eriksson, Gunilla Saei, Amir Ata Timmons, Zena Kitchener, Andrew C. Kalthoff, Daniela C. Lidén, Kerstin Makarov, Alexander A. Zubarev, Roman A. J Am Chem Soc [Image: see text] Analyzing the δ(2)H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher δ(2)H than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that “you are what you eat”. American Chemical Society 2022-02-02 2022-02-16 /pmc/articles/PMC8855419/ /pubmed/35107291 http://dx.doi.org/10.1021/jacs.1c12512 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Gharibi, Hassan
Chernobrovkin, Alexey L.
Eriksson, Gunilla
Saei, Amir Ata
Timmons, Zena
Kitchener, Andrew C.
Kalthoff, Daniela C.
Lidén, Kerstin
Makarov, Alexander A.
Zubarev, Roman A.
Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
title Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
title_full Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
title_fullStr Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
title_full_unstemmed Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
title_short Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
title_sort abnormal (hydroxy)proline deuterium content redefines hydrogen chemical mass
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855419/
https://www.ncbi.nlm.nih.gov/pubmed/35107291
http://dx.doi.org/10.1021/jacs.1c12512
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