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Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
[Image: see text] Analyzing the δ(2)H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at le...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855419/ https://www.ncbi.nlm.nih.gov/pubmed/35107291 http://dx.doi.org/10.1021/jacs.1c12512 |
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author | Gharibi, Hassan Chernobrovkin, Alexey L. Eriksson, Gunilla Saei, Amir Ata Timmons, Zena Kitchener, Andrew C. Kalthoff, Daniela C. Lidén, Kerstin Makarov, Alexander A. Zubarev, Roman A. |
author_facet | Gharibi, Hassan Chernobrovkin, Alexey L. Eriksson, Gunilla Saei, Amir Ata Timmons, Zena Kitchener, Andrew C. Kalthoff, Daniela C. Lidén, Kerstin Makarov, Alexander A. Zubarev, Roman A. |
author_sort | Gharibi, Hassan |
collection | PubMed |
description | [Image: see text] Analyzing the δ(2)H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher δ(2)H than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that “you are what you eat”. |
format | Online Article Text |
id | pubmed-8855419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-88554192022-02-22 Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass Gharibi, Hassan Chernobrovkin, Alexey L. Eriksson, Gunilla Saei, Amir Ata Timmons, Zena Kitchener, Andrew C. Kalthoff, Daniela C. Lidén, Kerstin Makarov, Alexander A. Zubarev, Roman A. J Am Chem Soc [Image: see text] Analyzing the δ(2)H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher δ(2)H than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that “you are what you eat”. American Chemical Society 2022-02-02 2022-02-16 /pmc/articles/PMC8855419/ /pubmed/35107291 http://dx.doi.org/10.1021/jacs.1c12512 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Gharibi, Hassan Chernobrovkin, Alexey L. Eriksson, Gunilla Saei, Amir Ata Timmons, Zena Kitchener, Andrew C. Kalthoff, Daniela C. Lidén, Kerstin Makarov, Alexander A. Zubarev, Roman A. Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass |
title | Abnormal
(Hydroxy)proline Deuterium Content Redefines
Hydrogen Chemical Mass |
title_full | Abnormal
(Hydroxy)proline Deuterium Content Redefines
Hydrogen Chemical Mass |
title_fullStr | Abnormal
(Hydroxy)proline Deuterium Content Redefines
Hydrogen Chemical Mass |
title_full_unstemmed | Abnormal
(Hydroxy)proline Deuterium Content Redefines
Hydrogen Chemical Mass |
title_short | Abnormal
(Hydroxy)proline Deuterium Content Redefines
Hydrogen Chemical Mass |
title_sort | abnormal
(hydroxy)proline deuterium content redefines
hydrogen chemical mass |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855419/ https://www.ncbi.nlm.nih.gov/pubmed/35107291 http://dx.doi.org/10.1021/jacs.1c12512 |
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