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The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model

BACKGROUND: The number of young patients with hepatocellular carcinoma (HCC) is increasing, but whether patients of different ages have a survival advantage is unclear. This study was conducted to investigate whether age differences in the Barcelona Clinic Liver Cancer (BCLC) classification system c...

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Autores principales: Yan, Huiwen, Wang, Xinhui, Liu, Xiaoli, Wang, Peng, Yu, Lihua, Zhou, Dongdong, Yang, Zhiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855543/
https://www.ncbi.nlm.nih.gov/pubmed/35180841
http://dx.doi.org/10.1186/s12885-022-09293-x
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author Yan, Huiwen
Wang, Xinhui
Liu, Xiaoli
Wang, Peng
Yu, Lihua
Zhou, Dongdong
Yang, Zhiyun
author_facet Yan, Huiwen
Wang, Xinhui
Liu, Xiaoli
Wang, Peng
Yu, Lihua
Zhou, Dongdong
Yang, Zhiyun
author_sort Yan, Huiwen
collection PubMed
description BACKGROUND: The number of young patients with hepatocellular carcinoma (HCC) is increasing, but whether patients of different ages have a survival advantage is unclear. This study was conducted to investigate whether age differences in the Barcelona Clinic Liver Cancer (BCLC) classification system contribute to the long-term survival outcomes of patients with HCC. METHODS: A total of 1602 patients with HCC admitted to the Beijing Ditan Hospital was included in this study. Patients were divided into younger (≤45 years) and older (> 45 years) groups. Factors determining overall survival and progression-free survival were analyzed using univariate and multivariate analyses with the Kaplan-Meier method and Cox proportional hazard regression model. We calculated the cumulative incidence function using the Fine-Gray model. The effect of mortality on age was also estimated using a restricted cubic spline. RESULTS: After matching, overall survival and progression-free survival were significantly better in younger patients than in older patients with BCLC stage 0-B (p = 0.015 and p = 0.017, respectively). In BCLC stage 0-B, all-cause mortality increased with age and increased rapidly around the age of 40 years (non-linear, p < 0.05). In BCLC stages 0-B, HCC-related and non-HCC-related deaths significantly differed between younger and older individuals (p = 0.0019). CONCLUSION: In stage BCLC 0-B, age affects the long-term prognosis of patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09293-x.
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spelling pubmed-88555432022-02-23 The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model Yan, Huiwen Wang, Xinhui Liu, Xiaoli Wang, Peng Yu, Lihua Zhou, Dongdong Yang, Zhiyun BMC Cancer Research BACKGROUND: The number of young patients with hepatocellular carcinoma (HCC) is increasing, but whether patients of different ages have a survival advantage is unclear. This study was conducted to investigate whether age differences in the Barcelona Clinic Liver Cancer (BCLC) classification system contribute to the long-term survival outcomes of patients with HCC. METHODS: A total of 1602 patients with HCC admitted to the Beijing Ditan Hospital was included in this study. Patients were divided into younger (≤45 years) and older (> 45 years) groups. Factors determining overall survival and progression-free survival were analyzed using univariate and multivariate analyses with the Kaplan-Meier method and Cox proportional hazard regression model. We calculated the cumulative incidence function using the Fine-Gray model. The effect of mortality on age was also estimated using a restricted cubic spline. RESULTS: After matching, overall survival and progression-free survival were significantly better in younger patients than in older patients with BCLC stage 0-B (p = 0.015 and p = 0.017, respectively). In BCLC stage 0-B, all-cause mortality increased with age and increased rapidly around the age of 40 years (non-linear, p < 0.05). In BCLC stages 0-B, HCC-related and non-HCC-related deaths significantly differed between younger and older individuals (p = 0.0019). CONCLUSION: In stage BCLC 0-B, age affects the long-term prognosis of patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09293-x. BioMed Central 2022-02-18 /pmc/articles/PMC8855543/ /pubmed/35180841 http://dx.doi.org/10.1186/s12885-022-09293-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yan, Huiwen
Wang, Xinhui
Liu, Xiaoli
Wang, Peng
Yu, Lihua
Zhou, Dongdong
Yang, Zhiyun
The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model
title The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model
title_full The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model
title_fullStr The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model
title_full_unstemmed The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model
title_short The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model
title_sort survival strength of younger patients in bclc stage 0-b of hepatocellular carcinoma: basing on competing risk model
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855543/
https://www.ncbi.nlm.nih.gov/pubmed/35180841
http://dx.doi.org/10.1186/s12885-022-09293-x
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