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Ablation of T cell–associated PD-1H enhances functionality and promotes adoptive immunotherapy

Programmed death-1 homolog (PD-1H) is a coinhibitory molecule that negatively regulates T cell–mediated immune responses. In this study, we determined whether ablation of T cell–associated PD-1H could enhance adoptive T cell therapy in experimental tumor models. The expression of PD-1H is upregulate...

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Detalles Bibliográficos
Autores principales:	Hu, Li, Chen, Ling, Xiao, Zexiu, Zheng, Xu, Chen, Yuangui, Xian, Na, Cho, Christina, Luo, Liqun, Huang, Gangxiong, Chen, Lieping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855794/ https://www.ncbi.nlm.nih.gov/pubmed/34905507 http://dx.doi.org/10.1172/jci.insight.148247

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